Sp-Cyclic AMPS (sodium salt) [142439-95-0]
Référence T21697-1mg
Conditionnement : 1mg
Marque : TargetMol
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Sp-Cyclic AMPS (sodium salt)
Copy Product InfoSp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3].
Cas No. 142439-95-0
Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sp-cAMPS sodium salt is an analog of cAMP that serves as a potent activator of cAMP-dependent PKA I and PKA II, and as a competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 μM. It also binds the PDE10 GAF domain with an EC50 of 40 μM [1] [2] [3]. |
| Targets & IC50 | PDE3A:47.6 μM (Ki), PDE10 GAF domain:50 μM (EC50) |
| In vitro | The glucagon-stimulated increases in the level of Ca 2+ can be mimicked by Sp-cAMPS. Treatment of hepatocytes with Sp-cAMPS which is the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon [4]. |
| In vivo | In chronic alcohol consumption (CAC) mice, direct infusion of the PKA activator (Sp-cAMPS) (1 μg/μL) into the prefrontal cortex significantly improves working memory performance in withdrawn animals and impairs it in water animals [5]. |
| Molecular Weight | 367.25 |
| Formula | C10H12N5NaO5PS+ |
| Cas No. | 142439-95-0 |
| Smiles | O[C@H]1[C@@H](O[C@@]2(06)[C@@]1(06)OP([S-])(OC2)=O)N3C4=NC=NC(N)=C4N=C3.[Na+] |
| Relative Density. | no data available |
| Storage | Keep away from direct sunlight,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |