Conditionnement : 50mg
Téléphone : +1 850 650 7790
Synonyms: Substance P acetate (33507-63-0 Free base), Neurokinin P acetate
| Description | Substance P acetate is a peptide mainly secreted by neurons and is involved in many biological processes including nociception and inflammation. Substance P acetate is a neuroinflammatory factor that can act as a neurotransmitter and neuromodulator in the central nervous system and can be used to study cardiovascular and neurological diseases. |
| In vitro | Desensitization and resensitization of Substance P (SP) mediated by the neurokinin 1 receptor (NK1-R) may be related to endocytosis and recycling of NK1-R. SP is intact at the cell surface and in early nuclear endosomes but is slowly degraded in perinuclear vesicles. substance P acetate induces lattice protein-dependent internalization of the NK1-R. SP/ NK1-R complex dissociates in acidified nuclear endosomes, SP is degraded, and NK1-R is recycled to the cell surface.Substance P acetate induces internalization of NK1-R in transfected epithelial cells. [1] |
| Synonyms | Substance P acetate (33507-63-0 Free base), Neurokinin P acetate |
| Molecular Weight | 1407.68 |
| Formula | C65H102N18O15S |
| Smiles | O=C([C@H]1N(CCC1)C([C@@H](N)CCCNC(N)=N)=O)N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O)=O.CC(O)=O |
| Sequence | H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂ |
| Sequence Short | RPKPQQFFGLM |
| Storage | Keep away from moisture,Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (35.52 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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