TCP1 alpha Polyclonal Antibody PE-Cy7 Conjugated
Référence MBS9462699-0,1mL
Conditionnement : 0.1mL
Marque : MyBiosource
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TCP1 Alpha (TCP1alpha) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9462699MBS9462699 is an antibody targeting TCP1alpha. Also known as TCP1 alpha Polyclonal Antibody PE-Cy7 Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
TCP1 alpha (TCP1alpha), Polyclonal Antibody
Full Product Name
TCP1 alpha Polyclonal Antibody PE-Cy7 Conjugated
Product Gene Name
anti-TCP1alpha antibody
Product Synonym Names
TCP1 alpha
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purity/Purification
affinity purified by Protein A
Preparation and Storage
Store at -20 degree C for one year. Avoid repeated freeze/thaw cycles.
Shipped at 4 degree C.
Shipped at 4 degree C.
Applications Tested/Suitable for anti-TCP1alpha antibody
Immunocytochemistry (ICC), Immunofluorescence (IF)
Application Notes for anti-TCP1alpha antibody
ICC: 1:50-200
IF: 1:50-200
IF: 1:50-200
Other Notes
Small volumes of anti-TCP1alpha antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for TCP1alpha. It may not necessarily be applicable to this product.
NCBI Official Full Name
T-complex protein 1 subunit alpha
NCBI Official Synonym Full Names
t-complex 1
NCBI Official Symbol
TCP1
NCBI Official Synonym Symbols
CCT1; CCTa; D6S230E; CCT-alpha; TCP-1-alpha
UniProt Protein Name
T-complex protein 1 subunit alpha
UniProt Synonym Protein Names
CCT-alpha
UniProt Gene Name
TCP1
UniProt Synonym Gene Names
CCT1; CCTA; TCP-1-alpha
UniProt Entry Name
TCPA_HUMAN
NCBI Protein Information
T-complex protein 1 subunit alpha; tailless complex polypeptide 1; T-complex protein 1, alpha subunit
NCBI Summary for TCP1alpha
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
Show more UniProt Comments for TCP1alpha
CCT-alpha: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin. Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Component of the BBS/CCT complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 AND CCT8. Belongs to the TCP-1 chaperonin family.
Protein type: Chaperone; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q25.3-q26
Cellular Component: chaperonin-containing T-complex; Golgi apparatus; centrosome; microtubule; pericentriolar material; acrosome; nuclear heterochromatin; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding
Biological Process: tubulin folding; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida
Show more Protein type: Chaperone; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 6q25.3-q26
Cellular Component: chaperonin-containing T-complex; Golgi apparatus; centrosome; microtubule; pericentriolar material; acrosome; nuclear heterochromatin; cytosol
Molecular Function: protein binding; ubiquitin protein ligase binding; unfolded protein binding; ATP binding
Biological Process: tubulin folding; 'de novo' posttranslational protein folding; cellular protein metabolic process; protein folding; binding of sperm to zona pellucida
Research Articles on TCP1alpha
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-TCP1alpha antibody
| Reference Product | PubMed Publications |
|---|---|
| CCT5 antibody | >102 publications with TCP1alpha and CCT5 |
| PPP2CB antibody | >1 publications with TCP1alpha and PPP2CB |
| PPP2CA antibody | >1 publications with TCP1alpha and PPP2CA |
Pathways associated with anti-TCP1alpha antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Assembly Of The Primary Cilium Pathway antibodies | Assembly Of The Primary Cilium Pathway Diagram |
| Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies | Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram |
| BBSome-mediated Cargo-targeting To Cilium Pathway antibodies | BBSome-mediated Cargo-targeting To Cilium Pathway Diagram |
| Cargo Trafficking To The Periciliary Membrane Pathway antibodies | Cargo Trafficking To The Periciliary Membrane Pathway Diagram |
| Chaperonin-mediated Protein Folding Pathway antibodies | Chaperonin-mediated Protein Folding Pathway Diagram |
| Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway antibodies | Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway Diagram |
| Folding Of Actin By CCT/TriC Pathway antibodies | Folding Of Actin By CCT/TriC Pathway Diagram |
| Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway antibodies | Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway Diagram |
| Metabolism Of Proteins Pathway antibodies | Metabolism Of Proteins Pathway Diagram |
| Organelle Biogenesis And Maintenance Pathway antibodies | Organelle Biogenesis And Maintenance Pathway Diagram |
Diseases associated with anti-TCP1alpha antibody
| Disease Name | Pubmed Publications |
|---|---|
| Carcinoma Antibodies | >9 publications with TCP1alpha and Carcinoma |
| Cardiovascular Diseases Antibodies | >5 publications with TCP1alpha and Cardiovascular Diseases |
| Inflammation Antibodies | >5 publications with TCP1alpha and Inflammation |
| Immune System Diseases Antibodies | >5 publications with TCP1alpha and Immune System Diseases |
| Heart Diseases Antibodies | >3 publications with TCP1alpha and Heart Diseases |
| Lung Diseases Antibodies | >3 publications with TCP1alpha and Lung Diseases |
| Lung Neoplasms Antibodies | >3 publications with TCP1alpha and Lung Neoplasms |
| Carcinoma, Hepatocellular Antibodies | >2 publications with TCP1alpha and Carcinoma, Hepatocellular |
| Liver Diseases Antibodies | >2 publications with TCP1alpha and Liver Diseases |
| Liver Neoplasms Antibodies | >2 publications with TCP1alpha and Liver Neoplasms |
Organs/Tissues associated with anti-TCP1alpha antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >15 publications with TCP1alpha and Blood |
| Testis Antibodies | >15 publications with TCP1alpha and Testis |
| Brain Antibodies | >11 publications with TCP1alpha and Brain |
| Liver Antibodies | >6 publications with TCP1alpha and Liver |
| Nerve Antibodies | >6 publications with TCP1alpha and Nerve |
| Heart Antibodies | >6 publications with TCP1alpha and Heart |
| Kidney Antibodies | >4 publications with TCP1alpha and Kidney |
| Lung Antibodies | >4 publications with TCP1alpha and Lung |
| Muscle Antibodies | >4 publications with TCP1alpha and Muscle |
| Embryonic Tissue Antibodies | >3 publications with TCP1alpha and Embryonic Tissue |