TGFBR1 Antibody (Phospho-S165)
Référence OAAI00768
Conditionnement : 100ug
Marque : Aviva Systems Biology
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TGFBR1 Antibody (Phospho-S165) (OAAI00768)
| Datasheets/Manuals | Printable datasheet for TGFBR1 Antibody (Phospho-S165) (OAAI00768) |
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| Publications | Yohei Kishi, Keiji Shimada, Tomomi Fujii, Tomoko Uchiyama, Chiharu Yoshimoto, Noboru Konishi, Chiho Ohbayashi, Hiroshi Kobayashi. Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium. PLoS One. 12, e0189522 (2017). 29253010WB 34638842 33723267 |
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| Predicted Species Reactivity | Human|Mouse|Rat |
| Product Format | Liquid. This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Application | ELISA, FC, IHC-Fr, IP, WB |
| :: | Positive Control: MCF7 |
| :: | Cellular Location: Membrane/Cytoplasm |
| Reconstitution and Storage | The antibodies are stable for 24 months from date of receipt when stored at -20°C to -70°C. The antibodies can be stored at 2-8°C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles. |
| Immunogen | A synthetic peptide derived from internal sequence (-EEDP-*S-LDRP) with a phosphorylation site at Serine 165 of mouse TGFbeta receptor type-1. This sequence is also identical within human, rat, mouse, chicken, bovine and dog species. |
| Purification | Affinity Purified |
| Concentration | 0.5 mg/ml |
| Target Post-Translational Modification | Phosphorylated |
| Specificity | This antibody recognizes human protein. The other species are not tested. |
| Application Info | WB: 0.1 - 1 ug/mL ELISA: 0.01 - 0.1 ug/mL IP: 2 - 5 ug/mL IHC: 2 - 10 ug/mL |
| Reference | Wrana,J.L., et al. TGF beta signals throμgh a heteromeric protein kinase receptor Complex. Cell 71 (6), 1003-1014 (1992). Tomoda,T., Kudoh,T., Noma,T., Nakazawa,A., Muramatsu,M. and Arai,K. Molecular cloning of a Mouse counterpart for Human TGF-beta type I receptor. Biochem. Biophys. Res. Commun. 198 (3), 1054-1062 (1994) |
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| Gene Symbol | TGFBR1 |
| Gene Full Name | transforming growth factor beta receptor 1 |
| Alias Symbols | AAT5;activin A receptor type II-like kinase, 53kDa;activin A receptor type II-like protein kinase of 53kD;activin receptor-like kinase 5;ACVRLK4;ALK5;ALK-5;ESS1;LDS1;LDS1A;LDS2A;MSSE;mutant transforming growth factor beta receptor I;serine/threonine-protein kinase receptor R4;SKR4;tbetaR-I;TBR-i;TBRI;TGF-beta receptor type-1;TGFR-1;transforming growth factor beta receptor I;transforming growth factor-beta receptor type I. |
| NCBI Gene Id | 7046 |
| Description of Target | Transforming growth factor beta isoforms (TGF-beta1, 2, 3) play vital roles in regulating cellular growth and differentiation, and they signal throμgh a highly restricted subset of receptors known as TGF-beta type I receptor (TbetaR-I) and TGF-beta type II receptor (TbetaR-II). Expression of T beta R-I is more ubiquitous than that of T beta R-II. There was no staining of T beta R-II in the central nervous system, while intense T beta R-I staining was found specifically in nervous tissues. Expression of T beta R-I and T beta R-II was mostly coincident with that of their ligands, sμggesting that TGF-beta s act as multiple mediators during organogenesis. TGF-beta binds with high affinity to its receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain, to form a dynamic dimer with phosphorylation in the cytoplasmic Ser/Thr residuals which cause its kinase activity and association with another TGF beta-binding protein, the type I receptor, to signal growth inhibition and early gene responses. |
| Uniprot ID | P36897 |
| Molecular Weight | 55 |
