TUBG1 Antibody
Référence OAEE00394
Conditionnement : 0.1mg(C100)
Marque : Aviva Systems Biology
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| Datasheets/Manuals | Printable datasheet for TUBG1 Antibody |
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| Predicted Species Reactivity | Animal|Plant|Protozoa |
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| Product Format | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | TU-32 |
| Isotype | IgG1 |
| Host | Mouse |
| Application | ICC|WB |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | human gamma-tubulin peptide EYHAATRPDYISWGTQ, amino acids 434-449 |
| Purification | Purified |
| Concentration | 1 mg/ml |
| Specificity | The antibody TU-32 recognizes an epitope (amino acids 434-449 in human) within C-terminus of gamma-tubulin, a 48 kDa structural constituent of cytoskeleton and microtubule organizing center (MTOC). |
| Formulation | Purified |
| Purity | > 95% (by SDS-PAGE) |
| Storage Buffer | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 |
| Reference | Katsetos CD, Dráberová E, Smejkalová B, Reddy G, Bertrand L, de Chadarévian JP, Legido A, Nissanov J, Baas PW, Dráber P: Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. Neurochem Res. 2007 Aug;32(8):1387-98. Sulimenko V, Dráberová E, Sulimenko T, Macurek L, Richterová V, Dráber P, Dráber P: Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases. J Immunol. 2006 Jun 15;176(12):7243-53. Katsetos CD, Reddy G, Dráberová E, Smejkalová B, Del Valle L, Ashraf Q, Tadevosyan A, Yelin K, Maraziotis T, Mishra OP, Mörk S, Legido A, Nissanov J, Baas PW, de Chadarévian JP, Dráber P: Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines. J Neuropathol Exp Neurol. 2006 May;65(5):465-77. Libusová L, Sulimenko T, Sulimenko V, Hozák P, Dráber P: gamma-Tubulin in Leishmania: cell cycle-dependent changes in subcellular localization and heterogeneity of its isoforms.Exp Cell Res. 2004 May 1;295(2):375-86. Sulimenko V, Sulimenko T, Poznanovic S, Nechiporuk-Zloy V, Böhm KJ, Macurek L, Unger E, Dráber P: Association of brain gamma-tubulins with alpha beta-tubulin dimers. Biochem J. 2002 Aug 1;365(Pt 3):889-95. Dráberová E, Macůrek L, Richterová V, Böhm KJ, Dráber P: Monoclonal antibody KN-01 against the heavy chain of kinesin. Folia Biol (Praha). 2002;48(2):77-9. Linhartová I, Novotná B, Sulimenko V, Dráberová E, Dráber P: Gamma-tubulin in chicken erythrocytes: changes in localization during cell differentiation and characterization of cytoplasmic complexes. Dev Dyn. 2002 Mar;223(2):229-40. Nohýnková E., Dráber P., Reishig J., Kulda J: Cell-cycle dependent localization of gamma-tubulin in early branching eukaryote, a diplomonad flagellate Giardia intestinalis. Eur. J. Cell Biol. 78: 438-445, 2000. Binarová P, Cenklová V, Hause B, Kubátová E, Lysák M, Dolezel J, Bögre L, Dráber P: Nuclear gamma-tubulin during acentriolar plant mitosis. Plant Cell. 2000 Mar;12(3):433-42. Binarová P., Doležel J., Hause B., Dráber P: Association of g-tubulin with kinetochore/centromeric region of plant chromosomes. Plant J. 14: 751-757, 1998. Nováková M, Dráberová E, Schürmann W, Czihak G, Viklický V, Dr-aber P: gamma-Tubulin redistribution in taxol-treated mitotic cells probed by monoclonal antibodies. Cell Motil Cytoskeleton. 1996;33(1):38-51. Dráberová L, Dráberová E, Surviladze Z, Dráber P, Dráber P. Protein tyrosine kinase p53/p56(lyn) forms complexes with gamma-tubulin in rat basophilic leukemia cells. Int Immunol. 1999 Nov;11(11):1829-39. Haren L, Remy MH, Bazin I, Callebaut I, Wright M, Merdes A.NEDD1-dependent recruitment of the gamma-tubulin ring complex to the centrosome is necessary for centriole duplication and spindle assembly. J Cell Biol. 2006 Feb 13;172(4):505-15. Wiese C, Zheng Y: Microtubule nucleation: gamma-tubulin and beyond. J Cell Sci. 2006 Oct 15;119(Pt 20):4143-53. |
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| Gene Symbol | TUBG1 |
| Gene Full Name | tubulin gamma 1 |
| Alias Symbols | CDCBM4, Gamma-1-tubulin, gamma-tubulin complex component 1, GCP-1, TUBG, TUBGCP1, tubulin gamma-1 chain, tubulin, gamma polypeptide. |
| NCBI Gene Id | 7283 |
| Protein Name | Tubulin gamma-1 chain |
| Description of Target | Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation. |
| Uniprot ID | P23258 |
| Protein Accession # | NP_001061.2 |
| Nucleotide Accession # | NM_001070.4 |
