Vinculin Antibody
Référence MBS8584071-0,1mL-AF647
Conditionnement : 0.1mL(AF647)
Marque : MyBiosource
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Vinculin (VCL) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8584071MBS8584071 is an antibody targeting VCL. Also known as Vinculin Antibody. Reactive in Human, Mouse, Rat, Chicken, Pig. Host: Rabbit. Rabbit polyclonal antibody to Vinculin More details
Product Overview
Online Datasheet in PDFProduct Name
Vinculin (VCL), Polyclonal Antibody
Full Product Name
Vinculin Antibody
Product Gene Name
anti-VCL antibody
Product Synonym Names
Vinculin; Metavinculin; MV
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Chicken, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of Vinculin protein.
Molecular Weight
123,799 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (75757872..75879918). Location: 10q22.2
OMIM
193065
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human Vinculin. The exact sequence is proprietary.
Product Categories/Family for anti-VCL antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-VCL antibody
Western Blot (WB)
Other Notes
Small volumes of anti-VCL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for VCL. It may not necessarily be applicable to this product.
NCBI Official Full Name
vinculin isoform VCL
NCBI Official Synonym Full Names
vinculin
NCBI Official Symbol
VCL
NCBI Official Synonym Symbols
MV; MVCL; CMD1W; CMH15
UniProt Protein Name
Vinculin
UniProt Synonym Protein Names
Metavinculin
Protein Family
Vinculin
UniProt Gene Name
VCL
UniProt Synonym Gene Names
MV
UniProt Entry Name
VINC_HUMAN
NCBI Protein Information
vinculin; metavinculin
NCBI Summary for VCL
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for VCL
Vinculin: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. Exhibits self-association properties. Interacts with NRAP and SORBS1. Interacts with TLN1. Interacts with SYNM. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin. Metavinculin is muscle-specific. Belongs to the vinculin/alpha-catenin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: protein complex; costamere; focal adhesion; extracellular region; intercellular junction; fascia adherens; cytosol; cell-matrix junction; actin cytoskeleton; cell-cell adherens junction; adherens junction; cytoskeleton; plasma membrane; vesicle
Molecular Function: protein binding; cadherin binding; beta-catenin binding; structural molecule activity; actin binding; alpha-catenin binding
Biological Process: lamellipodium biogenesis; platelet activation; platelet degranulation; apical junction assembly; muscle contraction; axon extension; cell-matrix adhesion; morphogenesis of an epithelium; blood coagulation; cell adhesion; cell motility; negative regulation of cell migration
Disease: Cardiomyopathy, Dilated, 1w
Show more Protein type: Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component: protein complex; costamere; focal adhesion; extracellular region; intercellular junction; fascia adherens; cytosol; cell-matrix junction; actin cytoskeleton; cell-cell adherens junction; adherens junction; cytoskeleton; plasma membrane; vesicle
Molecular Function: protein binding; cadherin binding; beta-catenin binding; structural molecule activity; actin binding; alpha-catenin binding
Biological Process: lamellipodium biogenesis; platelet activation; platelet degranulation; apical junction assembly; muscle contraction; axon extension; cell-matrix adhesion; morphogenesis of an epithelium; blood coagulation; cell adhesion; cell motility; negative regulation of cell migration
Disease: Cardiomyopathy, Dilated, 1w
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-VCL antibody
| Reference Product | PubMed Publications |
|---|---|
| PTK2 antibody | >7 publications with VCL and PTK2 |
| SRC antibody | >6 publications with VCL and SRC |
| PXN antibody | >3 publications with VCL and PXN |
| CTNNA1 antibody | >2 publications with VCL and CTNNA1 |
| ACTN1 antibody | >2 publications with VCL and ACTN1 |
| PRKCA antibody | >1 publications with VCL and PRKCA |
| GSN antibody | >1 publications with VCL and GSN |
Pathways associated with anti-VCL antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Adherens Junction Pathway antibodies | Adherens Junction Pathway Diagram |
| Adherens Junction Pathway antibodies | Adherens Junction Pathway Diagram |
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Bacterial Invasion Of Epithelial Cells Pathway antibodies | Bacterial Invasion Of Epithelial Cells Pathway Diagram |
| Bacterial Invasion Of Epithelial Cells Pathway antibodies | Bacterial Invasion Of Epithelial Cells Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Hemostasis Pathway antibodies | Hemostasis Pathway Diagram |
Diseases associated with anti-VCL antibody
| Disease Name | Pubmed Publications |
|---|---|
| Cardiovascular Diseases Antibodies | >33 publications with VCL and Cardiovascular Diseases |
| Neoplasms Antibodies | >26 publications with VCL and Neoplasms |
| Drug Toxicity Antibodies | >25 publications with VCL and Drug Toxicity |
| Nervous System Diseases Antibodies | >15 publications with VCL and Nervous System Diseases |
| Heart Diseases Antibodies | >15 publications with VCL and Heart Diseases |
| Brain Diseases Antibodies | >12 publications with VCL and Brain Diseases |
| Kidney Diseases Antibodies | >6 publications with VCL and Kidney Diseases |
| Neoplasm Metastasis Antibodies | >6 publications with VCL and Neoplasm Metastasis |
| Poisoning Antibodies | >5 publications with VCL and Poisoning |
| Lung Diseases Antibodies | >4 publications with VCL and Lung Diseases |
Organs/Tissues associated with anti-VCL antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >47 publications with VCL and Blood |
| Muscle Antibodies | >44 publications with VCL and Muscle |
| Vascular Antibodies | >20 publications with VCL and Vascular |
| Heart Antibodies | >16 publications with VCL and Heart |
| Testis Antibodies | >16 publications with VCL and Testis |
| Brain Antibodies | >14 publications with VCL and Brain |
| Lung Antibodies | >12 publications with VCL and Lung |
| Liver Antibodies | >10 publications with VCL and Liver |
| Kidney Antibodies | >10 publications with VCL and Kidney |
| Bone Antibodies | >8 publications with VCL and Bone |