WWOX Antibody
Référence MBS856096-0,1mL-AF647
Conditionnement : 0.1mL(AF647)
Marque : MyBiosource
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
Western blot analysis of extracts from HepG2 cells, using WWOX antibody.
WWOX Antibody
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS856096MBS856096 is an antibody targeting WWOX. Also known as WWOX Antibody. Reactive in Human, Mouse. More details
Product Overview
Online Datasheet in PDFProduct Name
WWOX, Antibody
Full Product Name
WWOX Antibody
Product Gene Name
anti-WWOX antibody
Product Synonym Names
WW domain-containing oxidoreductase; EC 1.1.1.-; Fragile site FRA16D oxidoreductase; WWOX; FOR; WOX1
Species Reactivity
Human, Mouse
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
WWOX antibody detects endogenous levels of total WWOX protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
23,868 Da
OMIM
133239
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human WWOX.
Product Categories/Family for anti-WWOX antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-WWOX antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-WWOX antibody
WB: 1:500~1:1000
ELISA: 1:20000
ELISA: 1:20000
Product References and Citations for anti-WWOX antibody
Bednarek A.K., Cancer Res. 60:2140-2145(2000). Ried K., Hum. Mol. Genet. 9:1651-1663(2000). Bednarek A.K., Cancer Res. 61:8068-8073(2001).
Other Notes
Small volumes of anti-WWOX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for WWOX. It may not necessarily be applicable to this product.
NCBI Official Full Name
WW domain-containing oxidoreductase isoform 4
NCBI Official Synonym Full Names
WW domain containing oxidoreductase
NCBI Official Symbol
WWOX
NCBI Official Synonym Symbols
FOR; WOX1; EIEE28; FRA16D; SCAR12; HHCMA56; PRO0128; SDR41C1; D16S432E
UniProt Protein Name
WW domain-containing oxidoreductase
UniProt Synonym Protein Names
Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1
Protein Family
WW domain-containing oxidoreductase
UniProt Gene Name
WWOX
UniProt Synonym Gene Names
FOR; SDR41C1; WOX1
NCBI Protein Information
WW domain-containing oxidoreductase
NCBI Summary for WWOX
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Show more UniProt Comments for WWOX
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with anti-WWOX antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| ErbB4 Signaling Events Pathway antibodies | ErbB4 Signaling Events Pathway Diagram |
| Nuclear Signaling By ERBB4 Pathway antibodies | Nuclear Signaling By ERBB4 Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By ERBB4 Pathway antibodies | Signaling By ERBB4 Pathway Diagram |
Diseases associated with anti-WWOX antibody
| Disease Name | Pubmed Publications |
|---|---|
| Carcinoma Antibodies | >92 publications with WWOX and Carcinoma |
| Breast Neoplasms Antibodies | >51 publications with WWOX and Breast Neoplasms |
| Lung Neoplasms Antibodies | >30 publications with WWOX and Lung Neoplasms |
| Chromosome Aberrations Antibodies | >28 publications with WWOX and Chromosome Aberrations |
| Ovarian Neoplasms Antibodies | >26 publications with WWOX and Ovarian Neoplasms |
| Neoplasms, Experimental Antibodies | >21 publications with WWOX and Neoplasms, Experimental |
| Neoplasm Metastasis Antibodies | >19 publications with WWOX and Neoplasm Metastasis |
| Nervous System Diseases Antibodies | >18 publications with WWOX and Nervous System Diseases |
| Carcinoma, Squamous Cell Antibodies | >18 publications with WWOX and Carcinoma, Squamous Cell |
| Cell Transformation, Neoplastic Antibodies | >17 publications with WWOX and Cell Transformation, Neoplastic |
Organs/Tissues associated with anti-WWOX antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Lung Antibodies | >36 publications with WWOX and Lung |
| Prostate Antibodies | >30 publications with WWOX and Prostate |
| Brain Antibodies | >24 publications with WWOX and Brain |
| Bone Antibodies | >22 publications with WWOX and Bone |
| Liver Antibodies | >20 publications with WWOX and Liver |
| Blood Antibodies | >16 publications with WWOX and Blood |
| Lymph Antibodies | >10 publications with WWOX and Lymph |
| Kidney Antibodies | >8 publications with WWOX and Kidney |
| Ovary Antibodies | >8 publications with WWOX and Ovary |
| Nerve Antibodies | >5 publications with WWOX and Nerve |