Orb1225436-10mg | XAV939 [284028-89-3] Biovalley

XAV939

SKU: orb1225436

Description

XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.(In Vitro):XAV-939 has activity against TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively.XAV-939 (0.3-30 μM; 3 or 10 days) enhances osteoblast differentiation of hBMSCs.XAV-939 (3 μM) promotes osteoblast differentiation of hMSCs via accumulation of SH3BP2.XAV-939 (3 μM; 10 days) upregulates the expression of OPG and downregulates the expression of RANKL in hBMSCs during osteoblast differentiation.XAV-939 suppresses Wnt/β-catenin signaling and promotes SFRP3 and SFRP4 expression.(In Vivo):XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo.

Images & Validation

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Key Properties

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CAS Number	284028-89-3
MW	312.31
Purity	>98% (HPLC)
Formula	C₁₄H₁₁F₃N₂OS
SMILES	O=C1C(CSCC2)=C2N=C(C3=CC=C(C(F)(F)F)C=C3)N1
Target	PPAR
Solubility	DMSO: 12 mg/mL (38.42 mM)

Bioactivity

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In Vitro	XAV-939 (GMP) (5 μM; 2 μM for 3 days; 1 μM) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation. XAV939 (GMP) promotes anterior CNS identity. RT-PCR Cell line: Human pluripotent stem cells (hPSCs). Concentration: 5 μM, 2 μM, 1 μM. Incubation time: 3 days. Result: Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.

In Vitro

XAV-939 (GMP) (5 μM; 2 μM for 3 days; 1 μM) induces human pluripotent stem cells (hPSCs) to post-mitotic cortical neurons differentiation. XAV939 (GMP) promotes anterior CNS identity. RT-PCR Cell line: Human pluripotent stem cells (hPSCs). Concentration: 5 μM, 2 μM, 1 μM. Incubation time: 3 days. Result: Showed downregulation of the pluripotency marker OCT4 and induction of neural and neuronal markers PAX6, FOXG1 and DCX, as well as markers of early born cortical neurons, including TBR1 (preplate, subplate and layer VI) and REELIN, in LSB+X/P/S/D conditions.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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XAV939 | XAV 939 | XAV-939

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XAV-939 [orb1307281]
Purity:
>98%
CAS Number:
284028-89-3
MW:
312.3
Formula:
C₁₄H₁₁F₃N₂OS
Sizes Available: 25 mg, 5 mg
IWR-1-endo [orb1226954]
Purity:
>98% (HPLC)
CAS Number:
1127442-82-3
MW:
409.44
Formula:
C₂₅H₁₉N₃O₃
Sizes Available: 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 g, 200 mg

Quick Database Links

Gene Symbol

PPAR

XAV939 [284028-89-3]

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