XRN2 Antibody
Référence MBS8582802-0,1mL-FITC
Conditionnement : 0.1mL(FITC)
Marque : MyBiosource
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XRN2 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582802MBS8582802 is an antibody targeting XRN2. Also known as XRN2 Antibody. Reactive in Human, Mouse, Bovine, Chicken, Monkey, Zebrafish. Host: Rabbit. Rabbit polyclonal antibody to XRN2 More details
Product Overview
Online Datasheet in PDFProduct Name
XRN2, Polyclonal Antibody
Full Product Name
XRN2 Antibody
Product Gene Name
anti-XRN2 antibody
Product Synonym Names
5'-3' exoribonuclease 2; DHM1-like protein; DHP protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Bovine, Chicken, Monkey, Zebrafish
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of XRN2 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
108,582 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (21283942..21370463). Location: 20p11.2-p11.1
OMIM
608851
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human XRN2. The exact sequence is proprietary.
Product Categories/Family for anti-XRN2 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-XRN2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-XRN2 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-XRN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for XRN2. It may not necessarily be applicable to this product.
NCBI Official Full Name
5'-3' exoribonuclease 2
NCBI Official Synonym Full Names
5'-3' exoribonuclease 2
NCBI Official Symbol
XRN2
UniProt Protein Name
5'-3' exoribonuclease 2
UniProt Synonym Protein Names
DHM1-like protein
UniProt Gene Name
XRN2
UniProt Synonym Gene Names
DHP protein
UniProt Entry Name
XRN2_HUMAN
NCBI Protein Information
5'-3' exoribonuclease 2; DHP protein; Dhm1-like protein (mouse homolog)
NCBI Summary for XRN2
This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene; however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for XRN2
XRN2: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.13.-; Ribonuclease; RNA processing; RNA-binding; Cell development/differentiation; Nucleolus
Chromosomal Location of Human Ortholog: 20p11.2-p11.1
Cellular Component: membrane; nucleolus; nucleus
Molecular Function: 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; zinc ion binding
Biological Process: RNA processing; regulation of transcription, DNA-dependent; RNA metabolic process; RNA catabolic process; spermatogenesis; cell growth; mRNA processing; DNA catabolic process, exonucleolytic; transcription termination
Show more Protein type: EC 3.1.13.-; Ribonuclease; RNA processing; RNA-binding; Cell development/differentiation; Nucleolus
Chromosomal Location of Human Ortholog: 20p11.2-p11.1
Cellular Component: membrane; nucleolus; nucleus
Molecular Function: 5'-3' exonuclease activity; 5'-3' exoribonuclease activity; nuclease activity; zinc ion binding
Biological Process: RNA processing; regulation of transcription, DNA-dependent; RNA metabolic process; RNA catabolic process; spermatogenesis; cell growth; mRNA processing; DNA catabolic process, exonucleolytic; transcription termination
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-XRN2 antibody
| Reference Product | PubMed Publications |
|---|---|
| EXOSC10 antibody | >1 publications with XRN2 and EXOSC10 |
| DOM3Z antibody | >1 publications with XRN2 and DOM3Z |
Pathways associated with anti-XRN2 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies | Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram |
| Chaperonin-mediated Protein Folding Pathway antibodies | Chaperonin-mediated Protein Folding Pathway Diagram |
| Metabolism Of Proteins Pathway antibodies | Metabolism Of Proteins Pathway Diagram |
| Protein Folding Pathway antibodies | Protein Folding Pathway Diagram |
| RNA Degradation Pathway antibodies | RNA Degradation Pathway Diagram |
| RNA Degradation Pathway antibodies | RNA Degradation Pathway Diagram |
| Ribosome Biogenesis In Eukaryotes Pathway antibodies | Ribosome Biogenesis In Eukaryotes Pathway Diagram |
| Ribosome Biogenesis In Eukaryotes Pathway antibodies | Ribosome Biogenesis In Eukaryotes Pathway Diagram |
| MRNA Processing Pathway antibodies | MRNA Processing Pathway Diagram |
Diseases associated with anti-XRN2 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >3 publications with XRN2 and Neoplasms |
| Anemia Antibodies | >1 publications with XRN2 and Anemia |
Organs/Tissues associated with anti-XRN2 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Lung Antibodies | >2 publications with XRN2 and Lung |
| Testis Antibodies | >2 publications with XRN2 and Testis |
| Bone Antibodies | >1 publications with XRN2 and Bone |
| Bone Marrow Antibodies | >1 publications with XRN2 and Bone Marrow |
| Salivary Gland Antibodies | >1 publications with XRN2 and Salivary Gland |
| Blood Antibodies | >1 publications with XRN2 and Blood |
| Liver Antibodies | >1 publications with XRN2 and Liver |
| Kidney Antibodies | >1 publications with XRN2 and Kidney |
| Brain Antibodies | >1 publications with XRN2 and Brain |