Reagents and instruments for immunology, cell biology and molecular biology.
 
Methylated Histones

Methylated Histones

Histone methylation is a key epigenetic post-translational modification in which methyl groups are added to lysine or arginine residues of histone proteins. Unlike acetylation, it does not alter histone charge but regulates chromatin accessibility by recruiting specific effector proteins, thereby controlling gene activation or repression.

Biological Significance

The function of histone methylation depends on the modified residue and methylation state. Active transcription is commonly associated with H3K4me3 and H3K36me3, whereas H3K9me3 and H3K27me3 promote heterochromatin formation and gene silencing. These modifications also contribute to DNA repair, genome stability, chromatin organization, and epigenetic memory.

Research Applications

  • Epigenetic studies: Investigation of transcriptional regulation, chromatin dynamics, and cellular differentiation.
  • Disease research: Analysis of methylation abnormalities associated with cancer, neurological disorders, and developmental diseases.
  • Experimental tools: Recombinant methylated histones, PTM-specific antibodies, ChIP-seq, CUT&Tag, and mass spectrometry enable accurate mapping and characterization of histone methylation.

Frequently Asked Questions (FAQ)

How can I quickly find a methylated histones product?

To find a methylated histones product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Biovalley stock several product codes in the methylated histones category?

Yes, Biovalley distributes several product references in the methylated histones category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for methylated histones products?

Yes, you can request a quote for methylated histones products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a methylated histones product is available to order?

The availability of a methylated histones product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.

What should I do if I cannot find the methylated histones product I am looking for?

If the methylated histones product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all methylated histones products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.

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