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Reagents and instruments for immunology, cell biology and molecular biology.

(-)-borneol [464-45-9]

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Cat# NB-64-25116-1mL

Size : 1mLx10mM(inDMSO)

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Phone : +1 850 650 7790

Brand : Neo Biotech

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Phone : +1 850 650 7790

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(-)-borneol

(Synonyms: L-Borneol) Copy Product Info

Synonyms: L-Borneol

Catalog No. T3741 Copy Product Info

Purity: 99.02%

(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.

Cas No. 464-45-9

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.02%

Appearance:Solid

Color:White

Product Introduction

(-)-borneol AI Summary

(-)-borneol exhibits a binding affinity against human UDP Glucuronosyltransferase 1A4 (UGT1A4), with a Km value of 1100000.0 nM, and shows varying bioactivities across different human recombinant UGT isoforms. It demonstrates low or no activity in UGT1A1, UGT2B15, and UGT2B7H, while displaying moderate to high activity in UGT2A1, UGT2B7Y, and UGT1A4. The compound also exhibits antifungal activity against Colletotrichum acutatum, Colletotrichum gloeosporioides, and Colletotrichum fragariae, as observed in direct bioautography assays using 4 uL in 2 mM acetone, with complete growth inhibition. Furthermore, (-)-borneol displays cytotoxicity against HEK293 cells with a CC50 greater than 3000000.0 nM and inhibits Marburg virus envelope glycoprotein-mediated cell entry with an IC50 of 203000.0 nM. However, it shows weaker inhibition of Vesicular stomatitis Indiana virus envelope glycoprotein G-mediated cell entry with an IC50 greater than 650000.0 nM, yielding a selectivity index greater than 14.0 for Marburg virus..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
Targets & IC50	GABA:237 μM(EC50)
Synonyms	L-Borneol

Chemical Properties

Molecular Weight	154.25
Formula	C₁₀H₁₈O
Cas No.	464-45-9
Smiles	C[C@]12C(C)(C)[C@](C[C@H]1O)(CC2)14
Relative Density.	0.992g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform: Soluble

DMSO: 250 mg/mL (1620.75 mM), Sonication is recommended.

Ethanol: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4830 mL	32.4149 mL	64.8298 mL	324.1491 mL
5 mM	1.2966 mL	6.4830 mL	12.9660 mL	64.8298 mL
10 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
20 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
50 mM	0.1297 mL	0.6483 mL	1.2966 mL	6.4830 mL
100 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

GABAReceptorGABA ReceptorGABAborneol

Related Tags: (-)-borneol chemical structure | (-)-borneol formula | (-)-borneol molecular weight