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DNA methyltransferases

DNA methyltransferases

DNA methyltransferases (DNMTs) are highly conserved enzymes that catalyze the transfer of a methyl group from S-adenosylmethionine (SAM) to cytosine residues within CpG dinucleotides, generating 5-methylcytosine (5mC). This epigenetic modification regulates gene expression, chromatin organization, genome stability, and normal development.

Major DNMT Family Members

The mammalian DNMT family comprises four principal enzymes and one regulatory cofactor with distinct biological functions:

  • DNMT1: Maintains DNA methylation patterns following DNA replication.
  • DNMT3A & DNMT3B: Establish de novo methylation during embryogenesis, germ cell development, and lineage specification.
  • DNMT2: Primarily methylates transfer RNA (tRNA), supporting RNA stability and stress responses.
  • DNMT3L: Catalytically inactive cofactor that enhances DNMT3A/3B activity during germline development.

Biological Significance

DNMTs regulate developmental epigenetic programming, transcriptional silencing, repetitive element suppression, and genome integrity. Aberrant DNMT expression or mutations contribute to cancer, developmental disorders, and age-related epigenetic alterations. Consequently, DNMT inhibitors such as azacitidine and decitabine are widely used epigenetic therapies for hematological malignancies and remain promising targets for precision medicine.


Frequently Asked Questions (FAQ)

Where can I find dna methyltransferases products on the Biovalley website?

dna methyltransferases products are available in this section and can be sorted by product families or sub-categories, such as DNMT activators, DNMT3A, DNMT3B. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.

What types of products are available in the dna methyltransferases category?

The dna methyltransferases category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The DNMT3A, DNMT siRNAs, DNMT activators sub-categories allow you to find the products that meet your needs more quickly.

How can I quickly find a dna methyltransferases product?

To find a dna methyltransferases product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Biovalley stock several product codes in the dna methyltransferases category?

Yes, Biovalley distributes several product references in the dna methyltransferases category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for dna methyltransferases products?

Yes, you can request a quote for dna methyltransferases products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a dna methyltransferases product is available to order?

The availability of a dna methyltransferases product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.

What should I do if I cannot find the dna methyltransferases product I am looking for?

If the dna methyltransferases product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all dna methyltransferases products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.