Reagents and instruments for immunology, cell biology and molecular biology.
 
Epigenetic enzymes and regulators

Epigenetic enzymes and regulators

Epigenetic enzymes and regulators control gene activity without changing the underlying DNA sequence. They achieve this through modifications of DNA, histones, and higher-order chromatin structure, thereby influencing the accessibility of genes to the transcriptional machinery. These factors are central to cell differentiation, development, aging, and disease states such as cancer.

Main Enzyme Families

The major enzyme groups involved in epigenetic regulation include DNA methyltransferases (DNMTs), ten-eleven translocation enzymes (TETs), histone acetyltransferases (HATs), histone deacetylases (HDACs), histone methyltransferases (HMTs), and histone demethylases (HDMs). DNMTs catalyze the addition of methyl groups to DNA, while TET enzymes participate in the oxidation and removal of DNA methylation marks. HATs and HDACs regulate histone acetylation status, which directly influences chromatin accessibility and transcriptional activity.

Chromatin Remodeling Regulators

In addition to modifying epigenetic marks, certain regulators directly alter chromatin architecture. The SWI/SNF chromatin remodeling family, including BRG1, repositions nucleosomes and modulates chromatin accessibility, thereby influencing cell-type-specific gene expression programs. These remodeling complexes are particularly important during development and cellular reprogramming, where they contribute to the maintenance of active, silent, or poised transcriptional states.

Biological Functions

Epigenetic enzymes and regulators are essential for lineage commitment, stem cell maintenance, and tissue-specific gene expression. They enable cells containing identical genomes to acquire distinct cellular identities through stable yet reversible transcriptional programs. These epigenetic mechanisms can also be propagated during cell division, supporting the maintenance of cellular memory across successive generations of daughter cells.


Frequently Asked Questions (FAQ)

Where can I find enzymes and regulators products on the Biovalley website?

enzymes and regulators products are available in this section and can be sorted by product families or sub-categories, such as HDAC inhibitors, Histone demethylase assays, Sirtuin activity assays. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.

What types of products are available in the enzymes and regulators category?

The enzymes and regulators category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The DNA methyltransferases, HMT assays, Histone demethylase assays sub-categories allow you to find the products that meet your needs more quickly.

How can I quickly find a enzymes and regulators product?

To find a enzymes and regulators product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Biovalley stock several product codes in the enzymes and regulators category?

Yes, Biovalley distributes several product references in the enzymes and regulators category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for enzymes and regulators products?

Yes, you can request a quote for enzymes and regulators products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a enzymes and regulators product is available to order?

The availability of a enzymes and regulators product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.

What should I do if I cannot find the enzymes and regulators product I am looking for?

If the enzymes and regulators product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all enzymes and regulators products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.