Reagents and instruments for immunology, cell biology and molecular biology.
 
Ten-Eleven Translocation proteins

Ten-Eleven Translocation proteins

Ten-Eleven Translocation (TET) proteins are DNA demethylation enzymes that regulate epigenetic plasticity, gene expression, and cell identity. The mammalian family comprises TET1, TET2, and TET3, which are extensively studied in developmental biology, stem cell research, and cancer epigenetics.

Core Function

TET enzymes sequentially oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxycytosine, promoting active DNA demethylation and the restoration of unmethylated cytosine through DNA repair pathways.

Biological Significance

  • Epigenetic regulation: Maintain DNA methylation balance and support pluripotency and differentiation.
  • Development: Participate in embryogenesis, gametogenesis, immune regulation, learning, and memory.
  • Disease relevance: Altered TET activity contributes to hematological malignancies and other epigenetic disorders, making these enzymes valuable biomarkers and therapeutic targets.
  • Research applications: Measurement of 5hmC is widely used to evaluate TET-dependent DNA demethylation in stem cell, developmental, and cancer studies.

Frequently Asked Questions (FAQ)

Where can I find tet proteins products on the Biovalley website?

tet proteins products are available in this section and can be sorted by product families or sub-categories, such as TET recombinant proteins, TET activity assay kits, TET activators. You can browse the catalogue tree or use the search bar with a product name, catalogue reference, brand or supplier.

What types of products are available in the tet proteins category?

The tet proteins category brings together various product references, consumables, reagents, kits, instruments or laboratory solutions, depending on the relevant product family. The TET recombinant proteins, TET antibodies, TET activity assay kits sub-categories allow you to find the products that meet your needs more quickly.

How can I quickly find a tet proteins product?

To find a tet proteins product, use the search function by name, product code, supplier, brand or sub-category. You can also browse the product families listed on the page to identify an available product code, an alternative or an equivalent product.

Does Biovalley stock several product codes in the tet proteins category?

Yes, Biovalley distributes several product references in the tet proteins category, sourced from specialist suppliers. Depending on the product family, references may vary in terms of format, packaging, brand, supplier, technical specifications or availability.

Can I request a quote for tet proteins products?

Yes, you can request a quote for tet proteins products from the product page or by contacting Biovalley (info@biovalley.fr). To help us process your enquiry, please provide, where possible, the product name, catalogue reference, required quantity, the supplier or brand you are looking for, and the country of delivery.

How can I find out if a tet proteins product is available to order?

The availability of a tet proteins product depends on the product code, supplier, packaging and country of delivery. For up-to-date information, please check the product details page or contact Biovalley with the product code or name of the product you are looking for.

What should I do if I cannot find the tet proteins product I am looking for?

If the tet proteins product you are looking for does not appear in the catalogue, please contact Biovalley with the available information: product name, reference number, supplier, brand, format or packaging. The team will be able to search for the reference number within its network of suppliers or suggest an available alternative.

Are all tet proteins products available under the same terms and conditions?

No. Ordering, delivery, storage and documentation conditions may vary depending on the product type, the supplier and the applicable regulations. Certain product codes may require specific approval, specialised transport, a safety data sheet or additional information prior to ordering.