CARD4 (NOD1) (NM_006092) Human Tagged Lenti ORF Clone
CAT#: RC203759L1
- LentiORF®
Lenti ORF clone of Human nucleotide-binding oligomerization domain containing 1 (NOD1), Myc-DDK-tagged
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Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Symbol | CARD4 |
| Synonyms | CARD4; CLR7.1; NLRC1 |
| Vector | pLenti-C-Myc-DDK |
| E. coli Selection | Chloramphenicol (34 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | The ORF insert of this clone is exactly the same as(RC203759). |
| Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
| ACCN | NM_006092 |
| ORF Size | 2859 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_006092.1 |
| RefSeq Size | 4506 bp |
| RefSeq ORF | 2862 bp |
| Locus ID | 10392 |
| UniProt ID | Q9Y239 |
| Cytogenetics | 7p14.3 |
| Domains | CARD, LRR, LRR_RI |
| Protein Families | Druggable Genome |
| Protein Pathways | Epithelial cell signaling in Helicobacter pylori infection, NOD-like receptor signaling pathway |
| MW | 107.7 kDa |
| Gene Summary | This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response to viral and parasitic infection. Major structural features of this protein include an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. Mutations in this gene are associated with asthma, inflammatory bowel disease, Behcet disease and sarcoidosis in human patients. [provided by RefSeq, Aug 2017] |
Documents
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Resources
Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| RC203759 | NOD1 (Myc-DDK-tagged)-Human nucleotide-binding oligomerization domain containing 1 (NOD1) | 872,00 EUR | |
| RC203759L2 | Lenti ORF clone of Human nucleotide-binding oligomerization domain containing 1 (NOD1), mGFP tagged | 1 172,00 EUR | |
| RC203759L3 | Lenti ORF clone of Human nucleotide-binding oligomerization domain containing 1 (NOD1), Myc-DDK-tagged | 1 172,00 EUR | |
| RC203759L4 | Lenti ORF clone of Human nucleotide-binding oligomerization domain containing 1 (NOD1), mGFP tagged | 1 172,00 EUR | |
| RG203759 | NOD1 (tGFP-tagged) - Human nucleotide-binding oligomerization domain containing 1 (NOD1) | 1 072,00 EUR | |
| SC316302 | NOD1 (untagged)-Human nucleotide-binding oligomerization domain containing 1 (NOD1) | 873,00 EUR | |
| SC323936 | NOD1 (untagged)-Human nucleotide-binding oligomerization domain containing 1 (NOD1) | 873,00 EUR |