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Reagents and instruments for immunology, cell biology and molecular biology.

DL-Norepinephrine hydrochloride [55-27-6]

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Cat# NB-64-05236-100mg

Size : 100mg

Contact local distributor :

Phone : +1 850 650 7790

Brand : Neo Biotech

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DL-Norepinephrine hydrochloride

(Synonyms: DL-lysine) Copy Product Info

Synonyms: DL-lysine

Catalog No. T13655 Copy Product Info

Purity: 99.94%

DL-Norepinephrine hydrochloride (DL-lysine) is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM.

Cas No. 55-27-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

Appearance:Solid

Color:White to Yellow

Product Introduction

DL-Norepinephrine hydrochloride AI Summary

DL-Norepinephrine hydrochloride exhibits multifaceted bioactivity as an inhibitor across a range of biological targets and pathogens. In enzymatic assays, it inhibits the JMJD2A-Tudor Domain with a potency of 89125.1 nM, Rango-Importin beta complex formation at 125892.5 nM, HP1-beta Chromodomain interactions with methylated histone tails at 70794.6 nM, Polymerase Iota at 50118.7 nM and 47443.6 nM, Polymerase Eta at 56234.1 nM and 84921.4 nM, Polymerase Kappa at 79432.8 nM, and Marburg Virus entry into cells at 31622.8 nM. Moreover, it induces DNA re-replication in SW480 colon adenocarcinoma cells with a potency of 82.0 nM and inhibits GLP-1 Receptor Inverse Agonists at 10000.0 nM. Furthermore, it shows inhibitory activity in the development of antimalarial drugs targeting AMA1-RON with a potency of 17782.8 nM. In microbial assays, DL-Norepinephrine hydrochloride has marginal antifungal activity against Candida albicans ATCC 90028 (4.08%) and a potentially stimulatory or non-inhibitory effect on Cryptococcus neoformans H99 ATCC 208821 (-2.98%). Its antibacterial activities include inhibitions of 0.24% against Escherichia coli ATCC 25922, 15.27% against Klebsiella pneumoniae MDR ATCC 70063, 7.4% against Pseudomonas aeruginosa ATCC 27853, 28.77% against Acinetobacter baumannii ATCC 19606, and 10.44% against Staphylococcus aureus MRSA ATCC 43300. These findings suggest that DL-Norepinephrine hydrochloride holds significant potential as a versatile inhibitor with applications across various biological and antimicrobial domains..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DL-Norepinephrine hydrochloride (DL-lysine) is a high-affinity basic amino acid substrate of amino acid transporter b0 + with a Km value in the range of 100-400 μM.
Synonyms	DL-lysine

Chemical Properties

Molecular Weight	205.64
Formula	C₈H₁₂ClNO₃
Cas No.	55-27-6
Smiles	Cl.NCC(O)c1ccc(O)c(O)c1
Relative Density.	1.397g/cm3

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240.00 mg/mL (1167.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (4.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8629 mL	24.3143 mL	48.6287 mL	243.1434 mL
5 mM	0.9726 mL	4.8629 mL	9.7257 mL	48.6287 mL
10 mM	0.4863 mL	2.4314 mL	4.8629 mL	24.3143 mL
20 mM	0.2431 mL	1.2157 mL	2.4314 mL	12.1572 mL
50 mM	0.0973 mL	0.4863 mL	0.9726 mL	4.8629 mL
100 mM	0.0486 mL	0.2431 mL	0.4863 mL	2.4314 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

β1-adrenoceptorα1-adrenoceptorDL-Norepinephrine HydrochlorideDLNorepinephrine hydrochlorideDL-NorepinephrineDL Norepinephrine hydrochlorideAdrenergicReceptorAdrenergic Receptor

Related Tags: DL-Norepinephrine hydrochloride chemical structure | DL-Norepinephrine hydrochloride formula | DL-Norepinephrine hydrochloride molecular weight

DL-Norepinephrine hydrochloride [55-27-6]

Cat# NB-64-05236-100mg

Contact local distributor :

Brand : Neo Biotech

Contact local distributor :

DL-Norepinephrine hydrochloride

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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