Human SIRT1 activation kit by CRISPRa
CAT#: GA108289
SIRT1 CRISPRa kit - CRISPR gene activation of human sirtuin 1
Find the corresponding CRISPRi Inhibitor Kit
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Specifications
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
| Symbol | SIRT1 |
| Locus ID | 23411 |
| Kit Components | GA108289G1, SIRT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108289G2, SIRT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108289G3, SIRT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Reference Data | |
| RefSeq | NM_001142498, NM_001314049, NM_012238 |
| UniProt ID | Q96EB6 |
| Synonyms | SIR2; SIR2alpha; SIR2L1 |
| Summary | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008] |
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| KN218134 | SIRT1 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN218134BN | SIRT1 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN218134LP | SIRT1 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN218134RB | SIRT1 - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
| KN418134 | SIRT1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR |