Ionomycin calcium [56092-82-1]
Cat# NB-64-02974-1mg
Size : 1mg
Brand : Neo Biotech
Contact local distributor :
Phone : +1 850 650 7790
Ionomycin calcium (Synonyms: SQ23377 calcium)
Catalog No. T11665 Copy Product Info
Purity: 98.11%
Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, demonstrating high specificity for divalent cations (Ca>Mg>Sr=Ba).
Ionomycin calcium
Copy Product InfoSynonyms SQ23377 calcium
Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, demonstrating high specificity for divalent cations (Ca>Mg>Sr=Ba).
Cas No. 56092-82-1
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, demonstrating high specificity for divalent cations (Ca>Mg>Sr=Ba). |
| In vitro | METHODS: N1E-115 cells were treated with Ionomycin calcium (0.2-10 µM) for 3-24 h. Cell viability was determined by trypan blue dye exclusion assay. RESULTS: Ionomycin calcium induced cell death in a concentration- and time-dependent manner. [1] METHODS: Fura-2-loaded mouse cerebellar astrocytes were treated with Ionomycin calcium (0.1-10 µM) for 35 min, and cell membrane Ca(2+) concentration was monitored by changes in the Fura-2 340/380 ratio. RESULTS: With Ionomycin calcium concentrations <1 µM, Ca(2+) declined slowly after an initial peak and reached a significantly lower level after 35 min. The peak Ca(2+) was maintained at a plateau stage with 2 µM Ionomycin calcium. Ionomycin calcium Ca(2+) at concentrations >2 µM was significantly higher than the initial peak after 35 min. [2] |
| In vivo | METHODS: To investigate the mechanism of demyelination induced in vivo, Ionomycin calcium (2-50 µM, 0.5 µL) was dorsal column injected into SD rats. RESULTS: Ionomycin calcium-injected rats showed varying degrees of lesions observed on days 1-21, including areas of localized edema, a few scattered demyelinated axons, and larger lesions containing up to 200 demyelinated or degenerated axons. [3] |
| Synonyms | SQ23377 calcium |
| Molecular Weight | 747.07 |
| Formula | C41H70CaO9 |
| Cas No. | 56092-82-1 |
| Smiles | O=C([O-])CC[C@@H](C)C[C@H](C)C[C@H](C)C(/C=C([O-])/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]1CC[C@]([C@@H]2O[C@](C)([C@H](O)C)CC2)(C)O1)=O.[Ca+2] |
| Relative Density. | no data available |
| Storage | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (12.05 mM), Sonication is recommended. | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 0.5 mg/mL (0.67 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
You might also be interested by the following products:
Cat#
Description
Cond.
Price Bef. VAT