RS 67333 hydrochloride [168986-60-5]
Cat# T23265-100mg
Size : 100mg
Brand : TargetMol
Contact local distributor :
Phone : +1 850 650 7790
RS 67333 hydrochloride [168986-60-5]
RS 67333 hydrochloride
(Synonyms: RS 67333 HCl, RS 67333 (hydrochloride)) Copy Product InfoRS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.
Cas No. 168986-60-5
For research use only—not for human use. No sales to individuals. Use as intended only.
Select Batch
Purity:98.78%
Appearance:Solid
Color:Yellow
COA HNMR LCMS
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research. |
| Targets & IC50 | 5-HT4 receptor:8.7 (pKi) |
| In vitro | RS 67333 hydrochloride exhibits affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT [1]. |
| Synonyms | RS 67333 HCl, RS 67333 (hydrochloride) |
| Molecular Weight | 389.36 |
| Formula | C19H30Cl2N2O2 |
| Cas No. | 168986-60-5 |
| Smiles | Cl.O=C(C=1C=C(Cl)C(N)=CC1OC)CCC2CCN(CCCC)CC2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | H2O: 9 mg/mL (23.11 mM), Sonication is recommended. | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.14 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||