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Result Data
Note

Result Data

Result Data

Inhibition of SIRT2 by Nicotinamide (IC50= 250 uM).

  • Specification

    Product Description

    SIRT2 Direct Fluorescent Screening Assay provides a fluorescence-based method for screening SIRT2 inhibitors or activators.

    Regulation Status

    For research use only (RUO)

    Storage Instruction

    Store the kit at -80°C temporarily. For best results, store the components as described in the protocol.

    Note

    Result Data

  • Applications

    Functional Study

  • Gene Info — SIRT2

    Entrez GeneID

    22933

    Gene Name

    SIRT2

    Gene Alias

    SIR2, SIR2L, SIR2L2

    Gene Description

    sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)

    Omim ID

    604480

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene. [provided by RefSeq

    Other Designations

    silencing information regulator 2-like|silent information regulator 2|sir2-related protein type 2|sirtuin 2|sirtuin type 2

  • Interactome