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> β-Amyloid Peptide, aa1-40

β-Amyloid Peptide, aa1-40

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Référence A2275-75A-1mg

Conditionnement : 1mg

Marque : US Biological

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A2275-75A β-Amyloid Peptide, aa1-40

Grade
Highly Purified
Shipping Temp
Blue Ice
Storage Temp
-20°C

Major constituent of plaques and tangles that occur in Alzheimer’s disease (AD) patients.

Sequence (linear): H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

Amino Acid Analysis: Confirms expected sequence

Peptide Content: ~85.1 ± 4%

Solubility: H2O, DMSO, HFIP (1,1,1,3,3,3-hexafluoro-2-propanol).

Storage and Stability:
Lyophilized powder may be stored at 4°C for short-term only. Stable for 12 months at -20°C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.



Applications
Purity: ~90% by HPLC and MS analysis|Concentration: As reported|Form: Supplied as a lyophilized powder.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Form
Supplied as a lyophilized powder.
Purity
~90% by HPLC and MS analysis
References
1.Borchelt, D.R. et al. (1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 19:939–945. 2.Arendash, G.W. et al. (1999) Intravascular beta-amyloid infusion increases blood pressure: implications for a vasoactive role of beta-amyloid in the pathogenesis of Alzheimer’s disease. Neuroscience Letters 268:17–20. 3.Yan, S.D. et al. (1999) Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity. (1999) J. Biol. Chem. 274:2145–2156. 4.Bradt, B.M. et al. (1999) Complement-dependent proinflammatory properties of the Alzheimer’s disease b-peptide. J. Exp. Med. 188:431–438. 5.Ulery, P.G. et al. (2000) Modulation of b-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP): evidence that LRP contributes to the pathogenesis of Alzheimer’s disease. J. Biol. Chem. 275:7410–7415 (cites the use of this peptide as a standard in ELISA).

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