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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

(S)-(+)-Carvone [2244-16-8]

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Référence NB-64-20825-1mL

Conditionnement : 1mLx10mM(inDMSO)

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(S)-(+)-Carvone

(Synonyms: (+)-Carvone) Copy Product Info

Synonyms: (+)-Carvone

Catalog No. T3245 Copy Product Info

Purity: 97.70%

(S)-(+)-Carvone is a compound that occurs naturally in several foods and has anticonvulsant activity.

Cas No. 2244-16-8

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.70%

Appearance:Liquid

Color:Transparent

Product Introduction

(S)-(+)-Carvone AI Summary

(S)-(+)-Carvone exhibits various bioactivities, including inhibitory activity against Aldehyde Dehydrogenase 1 (ALDH1A1) with potencies ranging from 22387.2 to 28183.8 nM and potency in inhibiting the Menin-MLL interaction in MLL-related leukemias at 39810.7 nM. It modulates lipid storage in Drosophila S3 cells (651.3 nM) and acts as an antagonist of thyroid hormone receptor beta signaling (17.8 nM). The compound delays the death of the malarial parasite plastid after a 96-hour incubation (18526.0 nM) and shows inhibitory activity against Regulator of G Protein Signaling (RGS) 4 (8436.8 nM). Additionally, it acts as an agonist of the antioxidant response element (ARE) signaling pathway (18833.6 nM) and as an antagonist of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway (59.6 nM), along with inhibitory activity against TDP-43 (17782.8 nM). (S)-(+)-Carvone also exhibits repellent activity against Tribolium castaneum (red flour beetle), with repellency values ranging from -10.0% to 96.0%. It has a logP value of 3.07. Moreover, it functions as an inhibitor of Electrophorus electricus (electric eel) acetylcholinesterase (AChE), with a Ki value of 300000.0 nM determined via the Ellman method-based colorimetry assay using acetylthiocholine iodide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(S)-(+)-Carvone is a compound that occurs naturally in several foods and has anticonvulsant activity.
Synonyms	(+)-Carvone

Chemical Properties

Molecular Weight	150.22
Formula	C₁₀H₁₄O
Cas No.	2244-16-8
Smiles	C(C)(=C)[C@@H]1CC(=O)C(C)=CC1
Relative Density.	0.96 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (332.85 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.6569 mL	33.2845 mL	66.5690 mL	332.8452 mL
5 mM	1.3314 mL	6.6569 mL	13.3138 mL	66.5690 mL
10 mM	0.6657 mL	3.3285 mL	6.6569 mL	33.2845 mL
20 mM	0.3328 mL	1.6642 mL	3.3285 mL	16.6423 mL
50 mM	0.1331 mL	0.6657 mL	1.3314 mL	6.6569 mL
100 mM	0.0666 mL	0.3328 mL	0.6657 mL	3.3285 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitD-?CarvoneCarvone(S)(+)Carvone(S) (+) Carvone

Related Tags: (S)-(+)-Carvone chemical structure | (S)-(+)-Carvone formula | (S)-(+)-Carvone molecular weight