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α-Tocotrienol [58864-81-6]

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Référence NB-64-45941-5mg

Conditionnement : 5mg

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Téléphone : +1 850 650 7790

Marque : Neo Biotech

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α-Tocotrienol

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Synonyms:

Catalog No. T9675 Copy Product Info

Purity: 99.94%

D-ALPHA-TOCOTRIENOL, an isoform of vitamin E, is found in vegetables, fruits, seeds, grains, oils and nuts.

Cas No. 58864-81-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.94%

Appearance:Viscous

Color:White

Product Information

α-Tocotrienol AI Summary

α-Tocotrienol demonstrates bioactivity related to the inhibition of cholesterol biosynthesis and affects lipid metabolism in both isolated rat hepatocytes and HepG2 cells. It inhibits HMGR (HMG-CoA Reductase) and shows inhibition of cholesterol synthesis from [14C]acetate in HepG2 cells. Additionally, it exhibits antiproliferative activity against human MCF7 and MDA-MB-231 cells, with IC50 values of greater than 20000.0 nM and 10000.0 nM, respectively, and a specific IC50 value of 1603245.39 nM for MCF7 cells. α-Tocotrienol also displays cytotoxic activity against mouse +SA cells with an IC50 value of 5000.0 nM in a 24-hour MTT assay. Furthermore, this compound shows moderate metabolic stability in vivo in rats and in human/mouse liver microsomes, with stability ranging from 5.0% to 15.0% in various assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	D-ALPHA-TOCOTRIENOL, an isoform of vitamin E, is found in vegetables, fruits, seeds, grains, oils and nuts.

Chemical Properties

Molecular Weight	424.6585
Formula	C₂₉H₄₄O₂
Cas No.	58864-81-6
Smiles	C\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC[C@]1(C)CCC2=C(O1)C(C)=C(C)C(O)=C2C

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture,Store at low temperature, Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125.00 mg/mL (294.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2.00 mg/mL (4.71 mM), Sonication is recommended.

10% DMSO+90% Saline: 10.00 mg/mL (23.55 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3548 mL	11.7742 mL	23.5483 mL	117.7417 mL
5 mM	0.4710 mL	2.3548 mL	4.7097 mL	23.5483 mL
10 mM	0.2355 mL	1.1774 mL	2.3548 mL	11.7742 mL
20 mM	0.1177 mL	0.5887 mL	1.1774 mL	5.8871 mL
50 mM	0.0471 mL	0.2355 mL	0.4710 mL	2.3548 mL
100 mM	0.0235 mL	0.1177 mL	0.2355 mL	1.1774 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

α-TocotrienolαTocotrienolα TocotrienolInhibitorinhibitHuman Endogenous MetaboliteEndogenousMetaboliteEndogenous Metabolitea-Tocotrienolalpha-Tocotrienol

Related Tags: α-Tocotrienol chemical structure | α-Tocotrienol formula | α-Tocotrienol molecular weight

α-Tocotrienol [58864-81-6]

Référence NB-64-45941-5mg

Contactez votre distributeur local :

Marque : Neo Biotech

Contactez votre distributeur local :

α-Tocotrienol

Product Information

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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