2-Iodoacetamide [144-48-9]
Référence NB-64-45250-1mL
Conditionnement : 1mLx10mM(inDMSO)
Marque : Neo Biotech
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2-Iodoacetamide
(Synonyms: Iodoacetamide) Copy Product InfoSynonyms: Iodoacetamide
Catalog No. T8897 Copy Product Info
Purity: 99.95%
Iodoacetamide, an alkylating agent, is commonly utilized for cysteine alkylation in proteomics sample preparation.
Cas No. 144-48-9
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.95%
Appearance:Solid
Color:White to Yellow
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Product Information
2-Iodoacetamide AI Summary
2-Iodoacetamide exhibits a broad spectrum of bioactivities and notable inhibitory capabilities. It is effective in inactivating rat muscle adenylate kinase and inhibiting adenylate kinase II, influencing enzyme inactivation half-time and rate. The compound also shows potent inhibition of horse liver alcohol dehydrogenase with a Ki value of 1905460.72 nM, and exhibits a logP value of 0.15. Furthermore, 2-Iodoacetamide significantly inhibits Aryl Hydrocarbon Activation (AHAT) by 99.0% at a 1 mM concentration using compound 8 and compound 10 as substrates. In addition, it inhibits thymidylate synthetase with a rate constant (k2) of 7.0 M^-1 at pH 7 and 24°C, and demonstrates potent inhibition of HIV YU2 gp120 binding to CD4 with an IC50 value of 33.3 nM. The compound also activates TRPA1 with an EC50 value of 357000.0 nM. In enzyme assays, 2-Iodoacetamide shows inhibitory activity against HSD17B4, RECQ1, JMJD2E, Tyrosyl-DNA Phosphodiesterase (TDP1), Cytochrome P450 2C19, Aldehyde Dehydrogenase 1 (ALDH1A1), and others, indicating extensive modulation across various biological pathways. It also displays significant activity in assays involving Lamin A Splicing, Histone Lysine Methyltransferases such as G9a, and the Regulator of G Protein Signaling (RGS) 4, among others. Moreover, 2-Iodoacetamide inhibits Pantoea ananatis lycopene cyclase, leaving 87.0% residual enzyme activity at 0.5 mM concentration and exhibits cysteine reactivity with a determined second-order rate constant of 25.0 /M/s assessed by 1H NMR. The compound also binds to human plasma coagulation factor XIIIa with a rate constant of 0.8 x 10^4/M/s and demonstrates a significant rate constant ratio to Glutathione. Overall, 2-Iodoacetamide’s diverse bioactivities and broad inhibitory profile underscore its potential as a multi-target therapeutic agent..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Iodoacetamide, an alkylating agent, is commonly utilized for cysteine alkylation in proteomics sample preparation. |
| Synonyms | Iodoacetamide |
| Molecular Weight | 184.96 |
| Formula | C2H4INO |
| Cas No. | 144-48-9 |
| Smiles | NC(=O)CI |
| Relative Density. | 2.1103 g/cm3 (Estimated) |
| Storage | Keep away from direct sunlight,Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (270.33 mM), Sonication is recommended.  H2O: 50 mg/mL (270.33 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.81 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||