7α-Hydroxycholesterol [566-26-7]
Référence T19161-5mg
Conditionnement : 5mg
Marque : TargetMol
Contactez votre distributeur local :
Téléphone : +1 850 650 7790
7α-Hydroxycholesterol
Copy Product Info
7α-Hydroxycholesterol, a cholesterol oxide formed through both enzymatic and non-enzymatic oxidation, can serve as a biomarker for lipid peroxidation.
Cas No. 566-26-7
For research use only—not for human use. No sales to individuals. Use as intended only.
Select Batch
Purity:99.98%
Appearance:Solid
Color:White
COA HPLC HNMR
Product Introduction
7α-Hydroxycholesterol AI Summary
7α-Hydroxycholesterol exhibits diverse bioactivities across several biological assays and cell types. It demonstrates cytotoxicity against human HT-29 cells with an IC50 value of 15,500.0 nM as measured by the Alamar Blue assay after 48 hours, indicating its potential as an anti-cancer agent. Additionally, it shows growth inhibition and cytotoxic effects on human SK-N-BE, rat C6, and mouse 158N cells based on trypan blue-based cell counting methods. Furthermore, 7α-Hydroxycholesterol acts as a competitive inhibitor for both ROR alpha and ROR gamma ligand binding domains, with Ki values of 12.0 nM and 10.0 nM, respectively. It also displays varying effects on cell viability in different assays: it generally promotes growth in HEK293T cells, and shows mixed viability effects in U2OS and human fibroblast cells. 7α-Hydroxycholesterol affects the thermal stability of protein domains differently, with significant impact on certain domains. Additionally, it shows bioactivities in GPCR beta-arrestin recruitment assays targeting multiple receptors, suggesting potential modulatory effects on various GPCR signaling pathways. These collective bioactivities highlight the compound's multifaceted biological interactions, warranting further investigation..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 7α-Hydroxycholesterol, a cholesterol oxide formed through both enzymatic and non-enzymatic oxidation, can serve as a biomarker for lipid peroxidation. |
| Molecular Weight | 402.65 |
| Formula | C27H46O2 |
| Cas No. | 566-26-7 |
| Smiles | 14[C@@]1(CC[C@@]2(14)[C@]3(14)[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3(14)CC[C@]12C)[C@H](C)CCCC(C)C |
| Relative Density. | 1.03g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (111.76 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 4 mg/mL (9.93 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||