Biovalley > ACTH - Adrenocorticotropic Hormone Protein
ACTH - Adrenocorticotropic Hormone Protein
Référence OPPA01044
Conditionnement : 2mg
Marque : Aviva Systems Biology
ACTH - Adrenocorticotropic Hormone Protein (OPPA01044)
| Datasheets/Manuals | Printable datasheet for OPPA01044 |
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| Product Format | The ACTH hormone was lyophilized with no additives. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder. |
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| Additional Information | Solubility: It is recommended to reconstitute the lyophilized ACTH in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. |
| :: | Product Description: Adrenocorticotropic hormone, as its name implies, stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex. Stimulates secretion of adrenal corticosteroids and induces growth of adrenal cortex. ACTH also called Tetracosactide directly activates G-proteins. A stimulator of adenylate cyclase and cAMP formation. Its molecular weight is 4541.3 having an amino acid sequence of H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH. |
| Reconstitution and Storage | Lyophilized Adrenocorticotropic Hormone although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution ACTH should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Purity | Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Gene Symbol | ACTH |
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| Alias Symbols | LPH, MSH, NPP, POC, ACTH, CLIP, OBAIRH |
| NCBI Gene Id | 5443 |
| Protein Name | Pro-opiomelanocortin |
| Description of Target | Adrenocorticotropic Hormone |
| Uniprot ID | P01189 |
| Protein Accession # | NP_000930.1 |
Protein interactions
| Name | # of Products |
|---|---|
| FGF10 | 20 |
| HLA-DRB3 | 82 |
| MC1R | 19 |
| MC2R | 18 |
| MC3R | 16 |
| MC4R | 25 |
| MC5R | 17 |
| MEP1A | 119 |
| NRD1 | 31 |
| VTN | 147 |
Biological pathways
| Name | # of Products |
|---|---|
| Cell-cell signaling | 763 |
| Cellular nitrogen compound metabolic process | 116 |
| Cellular pigmentation | 14 |
| Generation of precursor metabolites and energy | 84 |
| Hormone biosynthetic process | 84 |
| Negative regulation of tumor necrosis factor production | 93 |
| Neuropeptide signaling pathway | 134 |
| Peptide hormone processing | 70 |
| Positive regulation of transcription from RNA polymerase II promoter | 1210 |
| Regulation of appetite | 15 |
| Regulation of blood pressure | 94 |
Biological process
| Name | # of Products |
|---|---|
| Cell-cell signaling | 235 |
| Cellular nitrogen compound metabolic process | 173 |
| Cellular pigmentation | 3 |
| Generation of precursor metabolites and energy | 42 |
| Negative regulation of tumor necrosis factor production | 35 |
| Neuropeptide signaling pathway | 70 |
| Peptide hormone processing | 16 |
| Positive regulation of transcription from RNA polymerase II promoter | 968 |
| Regulation of appetite | 5 |
| Regulation of blood pressure | 59 |
| Signal transduction | 1058 |
| Small molecule metabolic process | 825 |
Cellular components
| Name | # of Products |
|---|---|
| Cytoplasm | 4549 |
| Extracellular region | 1573 |
| Extracellular space | 884 |
| Secretory granule | 77 |
Protein function
| Name | # of Products |
|---|---|
| G-protein coupled receptor binding | 103 |
| Hormone activity | 494 |
| Receptor binding | 932 |
| Type 1 melanocortin receptor binding | 18 |
| Type 3 melanocortin receptor binding | 18 |
| Type 4 melanocortin receptor binding | 18 |
Diseases
| Name | # of Products |
|---|---|
| Obesity | 164 |
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ACTH N-terminal Antibody (OAMA00627)Catalog #: OAMA00627Clone: 57Application: EIA,IHC-PFormat: Purified, Liquid -
ACTH ELISA Kit (Human) (OKEH00625)Catalog #: OKEH00625Application: ELISA-SandwichKit Range: 0.39-25ng/mLSensitivity: 0.10 ng/mL


