Active Colony Stimulating Factor 1, Macrophage (MCSF)
Référence MBS2125331-0,01mg
Conditionnement : 0.01mg
Marque : MyBiosource
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Gene Sequencing (extract)
SDS-PAGE
The binding activity of M-CSF with M-CSF-R.
Colony Stimulating Factor 1, Macrophage (MCSF) Active Protein
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2125331SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
Macrophage Colony Stimulating Factor (M-CSF), also known as CSF-1, is asecreted cytokine which influences hematopoietic stem cells to differentiateinto macrophages or other related cell types. M-CSF (or CSF-1) is a hematopoieticgrowth factor that is involved… More details
Product Overview
Online Datasheet in PDFProduct Name
Colony Stimulating Factor 1, Macrophage (MCSF), Active Protein
Full Product Name
Active Colony Stimulating Factor 1, Macrophage (MCSF)
Product Gene Name
MCSF active protein
Product Synonym Names
MCSF/Colony Stimulating Factor 1, Macrophage; CSF1; M-CSF; Lanimostim; Processed macrophage colony-stimulating factor 1
Sequence
Lys33~Glu2 62
Host
293F Cell
Form/Format
Freeze-dried powder
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity/Purification
Greater than 95% by SDS-PAGE
Preparation and Storage
Store at 2-8 degree C for one month, -80 degree C for 12 months
Stable for 12 months if correctly stored.
The thermal stability is described by the loss rate. The loss rate was determinedby accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and noobvious degradation and precipitation were observed. The loss rate is less than 5% within theexpiration date under appropriate storage condition.
Stable for 12 months if correctly stored.
The thermal stability is described by the loss rate. The loss rate was determinedby accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and noobvious degradation and precipitation were observed. The loss rate is less than 5% within theexpiration date under appropriate storage condition.
Molecular Weight
29,353 Da
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin
<1.0EU per 1ug (determined by the LAL method)
Tag
N-terminal His Tag
Biological Activity
Active
Expression System
Eukaryotic expression
Organism Species
Mouse
Isoelectric Point
5.1
Subcellular Location
Secreted
Reconstitution
Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0mg/mL. Do not vortex.
Product Categories/Family for MCSF active protein
Cytokine; Infection immunity; Active, eukaryotic recombinant
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for MCSF active protein
Cell culture, Activity Assays
Other Notes
Small volumes of MCSF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for MCSF purchase
MBS2125331 is an active protein targeting MCSF. Also known as Active Colony Stimulating Factor 1, Macrophage (MCSF). Host: 293F Cell.
Additional Details
NCBI/Uniprot data below describe general gene information for MCSF. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
macrophage colony-stimulating factor 1 isoform 2
NCBI Official Synonym Full Names
colony stimulating factor 1 (macrophage)
NCBI Official Symbol
Csf1
NCBI Official Synonym Symbols
op; Csfm; MCSF; C87615
UniProt Protein Name
Macrophage colony-stimulating factor 1
UniProt Gene Name
Csf1
UniProt Synonym Gene Names
Csfm; CSF-1; MCSF
UniProt Entry Name
CSF1_MOUSE
NCBI Protein Information
macrophage colony-stimulating factor 1; osteopetrosis
UniProt Comments for MCSF
M-CSF: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cytokine
Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; extracellular region; plasma membrane; integral to membrane; receptor complex
Molecular Function: protein binding; protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding
Biological Process: positive regulation of monocyte differentiation; ossification; macrophage differentiation; immune system process; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; positive regulation of odontogenesis of dentine-containing teeth; reproductive developmental process; osteoclast differentiation; positive regulation of multicellular organism growth; odontogenesis; cell proliferation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; positive regulation of cell proliferation; innate immune response; positive regulation of Ras protein signal transduction; inflammatory response; positive regulation of macrophage differentiation; positive regulation of cell-matrix adhesion; regulation of ossification; positive regulation of cell migration
Show more Protein type: Membrane protein, integral; Cytokine
Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; extracellular region; plasma membrane; integral to membrane; receptor complex
Molecular Function: protein binding; protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding
Biological Process: positive regulation of monocyte differentiation; ossification; macrophage differentiation; immune system process; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; positive regulation of odontogenesis of dentine-containing teeth; reproductive developmental process; osteoclast differentiation; positive regulation of multicellular organism growth; odontogenesis; cell proliferation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; positive regulation of cell proliferation; innate immune response; positive regulation of Ras protein signal transduction; inflammatory response; positive regulation of macrophage differentiation; positive regulation of cell-matrix adhesion; regulation of ossification; positive regulation of cell migration
Research Articles on MCSF
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Pathways associated with MCSF active protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokines And Inflammatory Response (BioCarta) Pathway antibodies | Cytokines And Inflammatory Response (BioCarta) Pathway Diagram |
| Hematopoietic Cell Lineage Pathway antibodies | Hematopoietic Cell Lineage Pathway Diagram |
| Hematopoietic Cell Lineage Pathway antibodies | Hematopoietic Cell Lineage Pathway Diagram |
| Osteoclast Differentiation Pathway antibodies | Osteoclast Differentiation Pathway Diagram |
| Osteoclast Differentiation Pathway antibodies | Osteoclast Differentiation Pathway Diagram |
| PI3K-Akt Signaling Pathway antibodies | PI3K-Akt Signaling Pathway Diagram |
| PI3K-Akt Signaling Pathway antibodies | PI3K-Akt Signaling Pathway Diagram |
| Rap1 Signaling Pathway antibodies | Rap1 Signaling Pathway Diagram |
Diseases associated with MCSF active protein
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >38 publications with MCSF and Inflammation |
| Carcinoma Antibodies | >26 publications with MCSF and Carcinoma |
| Necrosis Antibodies | >21 publications with MCSF and Necrosis |
| Breast Neoplasms Antibodies | >21 publications with MCSF and Breast Neoplasms |
| Adenocarcinoma Antibodies | >14 publications with MCSF and Adenocarcinoma |
| Lung Neoplasms Antibodies | >14 publications with MCSF and Lung Neoplasms |
| Neoplasms, Experimental Antibodies | >10 publications with MCSF and Neoplasms, Experimental |
| Lung Diseases Antibodies | >9 publications with MCSF and Lung Diseases |
| Liver Diseases Antibodies | >7 publications with MCSF and Liver Diseases |
| Osteitis Deformans Antibodies | >6 publications with MCSF and Osteitis Deformans |
Organs/Tissues associated with MCSF active protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >70 publications with MCSF and Blood |
| Bone Antibodies | >61 publications with MCSF and Bone |
| Bone Marrow Antibodies | >34 publications with MCSF and Bone Marrow |
| Lung Antibodies | >28 publications with MCSF and Lung |
| Brain Antibodies | >16 publications with MCSF and Brain |
| Connective Tissue Antibodies | >13 publications with MCSF and Connective Tissue |
| Lymph Node Antibodies | >12 publications with MCSF and Lymph Node |
| Kidney Antibodies | >10 publications with MCSF and Kidney |
| Intestine Antibodies | >10 publications with MCSF and Intestine |
| Spleen Antibodies | >9 publications with MCSF and Spleen |