Anti-PLCZ1 Polyclonal Antibody
Référence NB-64-114121-50uL
Conditionnement : 50uL
Marque : Neo Biotech
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Anti-PLCZ1 Polyclonal Antibody
(Synonyms: Testis-development protein NYD-SP27, PLCZ1, Phospholipase C-zeta-1 (PLC-zeta-1), Phosphoinositide phospholipase C-zeta-1, 5-bisphosphate phosphodiesterase zeta-1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1) Copy Product InfoSynonyms: Testis-development protein NYD-SP27, PLCZ1, Phospholipase C-zeta-1 (PLC-zeta-1), Phosphoinositide phospholipase C-zeta-1, 5-bisphosphate phosphodiesterase zeta-1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Catalog No. TMAB-01549 Copy Product Info
Anti-PLCZ1 Polyclonal Antibody is a Rabbit antibody targeting PLCZ1. Anti-PLCZ1 Polyclonal Antibody can be used in IF,IHC-Fr.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-PLCZ1 Polyclonal Antibody is a Rabbit antibody targeting PLCZ1. Anti-PLCZ1 Polyclonal Antibody can be used in IF,IHC-Fr. |
| Synonyms | Testis-development protein NYD-SP27, PLCZ1, Phospholipase C-zeta-1 (PLC-zeta-1), Phosphoinositide phospholipase C-zeta-1, 5-bisphosphate phosphodiesterase zeta-1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 |
| Ig Type | IgG |
| Reactivity | Human,Rat (predicted:Mouse,Dog,Pig,Cow,Horse) |
| Verified Activity | Paraformaldehyde-fixed, paraffin embedded (human prostate); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (PLCZ1) Polyclonal Antibody, Unconjugated (TMAB-01549) at 1:200 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody for 90 minutes, and DAPI for nucleus staining.  |
| Application | IF IHC-Fr |
| Recommended Dose | IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Tissue Specificity | Expressed specifically in testis and sperm. Weakly expressed in pancreatic-duct cells. Up-regulated in pancreatic-duct cells from patients with cystic fibrosis. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, PLCZ1 hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. It triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. PLCZ1 is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. It may exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. |
| Immunogen | KLH conjugated synthetic peptide: human PLCZ1 |
| Antigen Species | Human |
| Gene Name | PLCZ1 |
| Gene ID | 89869 |
| Protein Name | 1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase zeta-1 |
| Uniprot ID | Q86YW0 |
| Biology Area | Metabolism of lipids and lipoproteins,Lipid metabolism |
| Molecular Weight | Theoretical: 70 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Keywords
PLC-ζ-1PLC-zeta-1PLCZ 1PLC ζ1PLC zeta1Phospholipase C-ζ-1 (PLC-ζ-1)Phosphoinositide phospholipase C-ζ-15-bisphosphate phosphodiesterase ζ-11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase ζ-1
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