APC-Cy7 Linked Polyclonal Antibody to Alanine Aminotransferase (ALT)
Référence MBS2116516-1mL
Conditionnement : 1mL
Marque : MyBiosource
Alanine Aminotransferase (ALT) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2116516SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2116516 is an antibody targeting ALT. Also known as APC-Cy7 Linked Polyclonal Antibody to Alanine Aminotransferase (ALT). Reactive in Human, Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Alanine Aminotransferase (ALT), Polyclonal Antibody
Full Product Name
APC-Cy7 Linked Polyclonal Antibody to Alanine Aminotransferase (ALT)
Product Gene Name
anti-ALT antibody
Product Synonym Names
GPT; ALAT; SGPT; AAT1; GPT1; Serum Glutamic Pyruvic Transaminase; Alanine Transaminase; Glutamate pyruvate transaminase 1; Glutamic--alanine transaminase 1
Immunogen Sequence
Ile147~Phe 263
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
Concentration
>=100ug/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against ALT. It has been selected for its ability to recognize ALT in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: ALT (MBS2002664)
APC-CY7 Conjugated Antibody: ALT (MBS2116516)
APC-CY7 Conjugated Antibody: ALT (MBS2116516)
Matching Pairs
APC-CY7 Conjugated Antibody: ALT (MBS2116516)
Immunogen: ALT (MBS2009133)
Immunogen: ALT (MBS2009133)
Molecular Weight
54,637 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (145729465..145732555). Location: 8q24.3
OMIM
138200
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Sequence
Ile147~Phe263
Cross Reactivity
Human, Mouse, Rat
Conjugation
APC-Cy7
Product Categories/Family for anti-ALT antibody
Enzyme & Kinase; Infection Immunity; Hepatology
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ALT antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Other Notes
Small volumes of anti-ALT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for ALT. It may not necessarily be applicable to this product.
NCBI Official Full Name
alanine aminotransferase
NCBI Official Synonym Full Names
glutamic-pyruvate transaminase (alanine aminotransferase)
NCBI Official Symbol
GPT
NCBI Official Synonym Symbols
AAT1; ALT1; GPT1
UniProt Protein Name
Alanine aminotransferase 1
UniProt Synonym Protein Names
Glutamate pyruvate transaminase 1; GPT 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1
Protein Family
NAD--protein ADP-ribosyltransferase
UniProt Gene Name
GPT
UniProt Synonym Gene Names
AAT1; GPT1; ALT1; GPT 1
UniProt Entry Name
ALAT1_HUMAN
NCBI Protein Information
alanine aminotransferase 1; GPT 1; glutamic-alanine transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamate pyruvate transaminase 1
NCBI Summary for ALT
This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
Show more UniProt Comments for ALT
GPT: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.
Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.2; Transferase
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: cytosol
Molecular Function: alanine transaminase activity; pyridoxal phosphate binding
Biological Process: amino acid biosynthetic process; L-alanine catabolic process
Show more Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.2; Transferase
Chromosomal Location of Human Ortholog: 8q24.3
Cellular Component: cytosol
Molecular Function: alanine transaminase activity; pyridoxal phosphate binding
Biological Process: amino acid biosynthetic process; L-alanine catabolic process
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-ALT antibody
| Reference Product | PubMed Publications |
|---|---|
| PGP antibody | >19 publications with ALT and PGP |
| GOT2 antibody | >4 publications with ALT and GOT2 |
| LDHB antibody | >1 publications with ALT and LDHB |
Pathways associated with anti-ALT antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| 2-Oxocarboxylic Acid Metabolism Pathway antibodies | 2-Oxocarboxylic Acid Metabolism Pathway Diagram |
| 2-Oxocarboxylic Acid Metabolism Pathway antibodies | 2-Oxocarboxylic Acid Metabolism Pathway Diagram |
| Alanine And Aspartate Metabolism Pathway antibodies | Alanine And Aspartate Metabolism Pathway Diagram |
| Alanine, Aspartate And Glutamate Metabolism Pathway antibodies | Alanine, Aspartate And Glutamate Metabolism Pathway Diagram |
| Alanine, Aspartate And Glutamate Metabolism Pathway antibodies | Alanine, Aspartate And Glutamate Metabolism Pathway Diagram |
| Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies | Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram |
| Biosynthesis Of Amino Acids Pathway antibodies | Biosynthesis Of Amino Acids Pathway Diagram |
| Biosynthesis Of Amino Acids Pathway antibodies | Biosynthesis Of Amino Acids Pathway Diagram |
| Metabolism Pathway antibodies | Metabolism Pathway Diagram |
| Metabolism Of Amino Acids And Derivatives Pathway antibodies | Metabolism Of Amino Acids And Derivatives Pathway Diagram |
Diseases associated with anti-ALT antibody
| Disease Name | Pubmed Publications |
|---|---|
| Liver Diseases Antibodies | >899 publications with ALT and Liver Diseases |
| Drug Toxicity Antibodies | >606 publications with ALT and Drug Toxicity |
| Neoplasms Antibodies | >455 publications with ALT and Neoplasms |
| Poisoning Antibodies | >377 publications with ALT and Poisoning |
| Drug-Induced Liver Injury Antibodies | >339 publications with ALT and Drug-Induced Liver Injury |
| Hepatitis Antibodies | >333 publications with ALT and Hepatitis |
| Necrosis Antibodies | >250 publications with ALT and Necrosis |
| Cardiovascular Diseases Antibodies | >208 publications with ALT and Cardiovascular Diseases |
| Nervous System Diseases Antibodies | >199 publications with ALT and Nervous System Diseases |
| Liver Neoplasms Antibodies | >163 publications with ALT and Liver Neoplasms |
Organs/Tissues associated with anti-ALT antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Liver Antibodies | >1699 publications with ALT and Liver |
| Kidney Antibodies | >327 publications with ALT and Kidney |
| Heart Antibodies | >178 publications with ALT and Heart |
| Lung Antibodies | >158 publications with ALT and Lung |
| Brain Antibodies | >144 publications with ALT and Brain |
| Skin Antibodies | >125 publications with ALT and Skin |
| Intestine Antibodies | >82 publications with ALT and Intestine |
| Mixed Antibodies | >73 publications with ALT and Mixed |
| Stomach Antibodies | >57 publications with ALT and Stomach |
| Pancreas Antibodies | >39 publications with ALT and Pancreas |


