APC Linked Polyclonal Antibody to Annexin A2 (ANXA2)
Référence MBS2134267-1mL
Conditionnement : 1mL
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Annexin A2 (ANXA2) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2134267MBS2134267 is an antibody targeting ANXA2. Also known as APC Linked Polyclonal Antibody to Annexin A2 (ANXA2). Reactive in Human, Mouse, Rat, Pig. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Annexin A2 (ANXA2), Polyclonal Antibody
Full Product Name
APC Linked Polyclonal Antibody to Annexin A2 (ANXA2)
Product Gene Name
anti-ANXA2 antibody
Product Synonym Names
ANXA2/Annexin A2; ANXA2; ANX2L4; CAL1H; LIP2; LPC2; LPC2D; P36; PAPIV; Protein I; Chromobindin8; Calpactin1 heavy chain; Lipocortin II; Placental anticoagulant protein IV
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Pig
Form/Format
Liquid; PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
>=0.1mg/mL (Please refer to the vial label for the specific concentration.) (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against ANXA2. It has been selected for its ability to recognize ANXA2 in immunohistochemical staining and western blotting.
Preparation and Storage
Store at 2 degree C to 8 degree C for frequent use, 20 degree C for 24 months
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: ANXA2 (MBS2139627)
APC Conjugated Antibody: ANXA2 (MBS2134267)
APC Conjugated Antibody: ANXA2 (MBS2134267)
Molecular Weight
38,604 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (60639350..60690185, complement). Location: 15q22.2
OMIM
151740
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen Type
Prokaryotic Recombinant proteins/RP
Sequence of Immunogen
Met1~Asp339
Conjugation
APC
Product Categories/Family for anti-ANXA2 antibody
Signal transduction; Tumor immunity; Bone metabolism; Primary, APC labeled
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-ANXA2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
Application Notes for anti-ANXA2 antibody
WB: 0.52ug/mL
IHC: 520ug/mL
ICC: 520ug/mL
IHC: 520ug/mL
ICC: 520ug/mL
Other Notes
Small volumes of anti-ANXA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for ANXA2. It may not necessarily be applicable to this product.
NCBI Official Full Name
annexin A2 isoform 2
NCBI Official Synonym Full Names
annexin A2
NCBI Official Symbol
ANXA2
NCBI Official Synonym Symbols
P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV
UniProt Protein Name
Annexin A2
UniProt Synonym Protein Names
Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36
Protein Family
Annexin
UniProt Gene Name
ANXA2
UniProt Synonym Gene Names
ANX2; ANX2L4; CAL1H; LPC2D; PAP-IV
UniProt Entry Name
ANXA2_HUMAN
NCBI Protein Information
annexin A2; annexin-2; protein I; annexin II; lipocortin II; chromobindin 8; chromobindin-8; calpactin I heavy chain; calpactin-1 heavy chain; calpactin I heavy polypeptide; placental anticoagulant protein IV
NCBI Summary for ANXA2
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for ANXA2
ANXA2: a calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10 2 heavy chains of ANXA2. May cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.
Protein type: Motility/polarity/chemotaxis; Lipid-binding; Calcium-binding
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component: extrinsic to plasma membrane; extracellular space; protein complex; cell surface; lysosomal membrane; late endosome membrane; early endosome; lipid particle; cell cortex; lipid raft; extracellular matrix; ruffle; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; basement membrane; midbody; nucleus; sarcolemma; endosome; vesicle
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; cytoskeletal protein binding; calcium ion binding; calcium-dependent protein binding; Rab GTPase binding
Biological Process: positive regulation of fibroblast proliferation; fibrinolysis; collagen fibril organization; negative regulation of catalytic activity; protein heterotetramerization; positive regulation of vesicle fusion; angiogenesis; positive regulation of binding; positive regulation of protein amino acid phosphorylation; lipid raft formation; body fluid secretion; membrane budding
Show more Protein type: Motility/polarity/chemotaxis; Lipid-binding; Calcium-binding
Chromosomal Location of Human Ortholog: 15q22.2
Cellular Component: extrinsic to plasma membrane; extracellular space; protein complex; cell surface; lysosomal membrane; late endosome membrane; early endosome; lipid particle; cell cortex; lipid raft; extracellular matrix; ruffle; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; basement membrane; midbody; nucleus; sarcolemma; endosome; vesicle
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; protein binding; calcium-dependent phospholipid binding; phospholipase A2 inhibitor activity; cytoskeletal protein binding; calcium ion binding; calcium-dependent protein binding; Rab GTPase binding
Biological Process: positive regulation of fibroblast proliferation; fibrinolysis; collagen fibril organization; negative regulation of catalytic activity; protein heterotetramerization; positive regulation of vesicle fusion; angiogenesis; positive regulation of binding; positive regulation of protein amino acid phosphorylation; lipid raft formation; body fluid secretion; membrane budding
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-ANXA2 antibody
| Reference Product | PubMed Publications |
|---|---|
| S100A10 antibody | >27 publications with ANXA2 and S100A10 |
| SRC antibody | >8 publications with ANXA2 and SRC |
| PLG antibody | >4 publications with ANXA2 and PLG |
| S100A6 antibody | >4 publications with ANXA2 and S100A6 |
| S100A4 antibody | >2 publications with ANXA2 and S100A4 |
| PLAT antibody | >2 publications with ANXA2 and PLAT |
| CDC42 antibody | >2 publications with ANXA2 and CDC42 |
| PHB antibody | >1 publications with ANXA2 and PHB |
| GRB2 antibody | >1 publications with ANXA2 and GRB2 |
| DYSF antibody | >1 publications with ANXA2 and DYSF |
Pathways associated with anti-ANXA2 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Prostaglandin Synthesis And Regulation Pathway antibodies | Prostaglandin Synthesis And Regulation Pathway Diagram |
Diseases associated with anti-ANXA2 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >71 publications with ANXA2 and Neoplasms |
| Adenocarcinoma Antibodies | >20 publications with ANXA2 and Adenocarcinoma |
| Neoplasm Metastasis Antibodies | >15 publications with ANXA2 and Neoplasm Metastasis |
| Cardiovascular Diseases Antibodies | >15 publications with ANXA2 and Cardiovascular Diseases |
| Inflammation Antibodies | >15 publications with ANXA2 and Inflammation |
| Liver Diseases Antibodies | >14 publications with ANXA2 and Liver Diseases |
| Neoplasm Invasiveness Antibodies | >13 publications with ANXA2 and Neoplasm Invasiveness |
| Necrosis Antibodies | >12 publications with ANXA2 and Necrosis |
| Carcinoma, Hepatocellular Antibodies | >11 publications with ANXA2 and Carcinoma, Hepatocellular |
| Liver Neoplasms Antibodies | >11 publications with ANXA2 and Liver Neoplasms |
Organs/Tissues associated with anti-ANXA2 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >48 publications with ANXA2 and Blood |
| Vascular Antibodies | >29 publications with ANXA2 and Vascular |
| Bone Antibodies | >27 publications with ANXA2 and Bone |
| Liver Antibodies | >22 publications with ANXA2 and Liver |
| Lung Antibodies | >13 publications with ANXA2 and Lung |
| Brain Antibodies | >12 publications with ANXA2 and Brain |
| Muscle Antibodies | >11 publications with ANXA2 and Muscle |
| Prostate Antibodies | >9 publications with ANXA2 and Prostate |
| Bone Marrow Antibodies | >9 publications with ANXA2 and Bone Marrow |
| Connective Tissue Antibodies | >8 publications with ANXA2 and Connective Tissue |