Apolipoprotein C2, Human Plasma, VLDL
Référence MBS135989-0,1mg
Conditionnement : 0.1mg
Marque : MyBiosource
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Apolipoprotein C2 (APOC2) Native Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS135989Apo CII activates lipoprotein lipase which then hydrolyzes VLDL triglyceride to form IDL (intermediate density lipoproteins). The concentration of Apo CII in normal plasma is 3-8 mg per 100 ml. Prepared from fresh, non-frozen plasma shown to be non reactive… More details
Product Overview
Online Datasheet in PDFProduct Name
Apolipoprotein C2 (APOC2), Native Protein
Full Product Name
Apolipoprotein C2, Human Plasma, VLDL
Product Gene Name
APOC2 native protein
Host
Human
Form/Format
Lyophilized powder
Purity/Purification
>95% by SDS-PAGE analysis
Preparation and Storage
Recommended Storage: At -70 degree C
Minimum Shelf Life: 3 years from delivery
Shipping Condition: Cold pack
Minimum Shelf Life: 3 years from delivery
Shipping Condition: Cold pack
Other Notes
Small volumes of APOC2 native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for APOC2 purchase
MBS135989 is a native protein targeting APOC2. Also known as Apolipoprotein C2, Human Plasma, VLDL. Host: Human.
Additional Details
NCBI/Uniprot data below describe general gene information for APOC2. It may not necessarily be applicable to this product.
NCBI Official Full Name
apolipoprotein C-II
NCBI Official Synonym Full Names
apolipoprotein C-II
NCBI Official Symbol
APOC2
NCBI Official Synonym Symbols
APO-CII; APOC-II
UniProt Protein Name
Apolipoprotein C-II
UniProt Synonym Protein Names
Apolipoprotein C2Proapolipoprotein C-II; ProapoC-II
Protein Family
Apolipoprotein
UniProt Gene Name
APOC2
UniProt Synonym Gene Names
APC2; Apo-CII; ApoC-II; ProapoC-II
UniProt Entry Name
APOC2_HUMAN
NCBI Protein Information
apolipoprotein C-II; apolipoprotein C2
NCBI Summary for APOC2
This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is secreted in plasma where it is a component of very low density lipoprotein. This protein activates the enzyme lipoprotein lipase, which hydrolyzes triglycerides and thus provides free fatty acids for cells. Mutations in this gene cause hyperlipoproteinemia type IB, characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring upstream apolipoprotein C-IV (APOC4) gene. [provided by RefSeq, Mar 2011]
Show more UniProt Comments for APOC2
APOC2: Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B). It is an autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis. Belongs to the apolipoprotein C2 family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: extracellular space; chylomicron; early endosome; extracellular region
Molecular Function: phospholipase binding; protein homodimerization activity; lipase inhibitor activity; lipid binding; phospholipase activator activity
Biological Process: phototransduction, visible light; positive regulation of fatty acid biosynthetic process; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; negative regulation of catalytic activity; positive regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; negative regulation of lipid metabolic process; retinoid metabolic process; lipid catabolic process
Disease: Apolipoprotein C-ii Deficiency
Show more Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: extracellular space; chylomicron; early endosome; extracellular region
Molecular Function: phospholipase binding; protein homodimerization activity; lipase inhibitor activity; lipid binding; phospholipase activator activity
Biological Process: phototransduction, visible light; positive regulation of fatty acid biosynthetic process; negative regulation of cholesterol transport; lipoprotein metabolic process; cholesterol efflux; cholesterol homeostasis; reverse cholesterol transport; phospholipid efflux; negative regulation of catalytic activity; positive regulation of lipoprotein lipase activity; negative regulation of receptor-mediated endocytosis; negative regulation of lipid metabolic process; retinoid metabolic process; lipid catabolic process
Disease: Apolipoprotein C-ii Deficiency
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with APOC2 native protein
| Reference Product | PubMed Publications |
|---|---|
| APOE native protein | >227 publications with APOC2 and APOE |
| LPL native protein | >185 publications with APOC2 and LPL |
| APOB native protein | >146 publications with APOC2 and APOB |
| APOA5 native protein | >36 publications with APOC2 and APOA5 |
| APOC3 native protein | >16 publications with APOC2 and APOC3 |
| APOA1 native protein | >14 publications with APOC2 and APOA1 |
| APOA2 native protein | >12 publications with APOC2 and APOA2 |
| APOA4 native protein | >7 publications with APOC2 and APOA4 |
Pathways associated with APOC2 native protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Chylomicron-mediated Lipid Transport Pathway antibodies | Chylomicron-mediated Lipid Transport Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| Diseases Associated With Visual Transduction Pathway antibodies | Diseases Associated With Visual Transduction Pathway Diagram |
| HDL-mediated Lipid Transport Pathway antibodies | HDL-mediated Lipid Transport Pathway Diagram |
| Lipid Digestion, Mobilization, And Transport Pathway antibodies | Lipid Digestion, Mobilization, And Transport Pathway Diagram |
| Lipoprotein Metabolism Pathway antibodies | Lipoprotein Metabolism Pathway Diagram |
| Metabolism Pathway antibodies | Metabolism Pathway Diagram |
| Metabolism Of Lipids And Lipoproteins Pathway antibodies | Metabolism Of Lipids And Lipoproteins Pathway Diagram |
| Retinoid Metabolism And Transport Pathway antibodies | Retinoid Metabolism And Transport Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
Diseases associated with APOC2 native protein
| Disease Name | Pubmed Publications |
|---|---|
| Dyslipidemias Antibodies | >263 publications with APOC2 and Dyslipidemias |
| Cardiovascular Diseases Antibodies | >97 publications with APOC2 and Cardiovascular Diseases |
| Atherosclerosis Antibodies | >88 publications with APOC2 and Atherosclerosis |
| Hyperlipoproteinemia Type I Antibodies | >44 publications with APOC2 and Hyperlipoproteinemia Type I |
| Liver Diseases Antibodies | >31 publications with APOC2 and Liver Diseases |
| Kidney Diseases Antibodies | >28 publications with APOC2 and Kidney Diseases |
| Fatty Liver Antibodies | >25 publications with APOC2 and Fatty Liver |
| Brain Diseases Antibodies | >24 publications with APOC2 and Brain Diseases |
| Inflammation Antibodies | >13 publications with APOC2 and Inflammation |
| Carcinoma Antibodies | >13 publications with APOC2 and Carcinoma |
Organs/Tissues associated with APOC2 native protein
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Liver Antibodies | >148 publications with APOC2 and Liver |
| Heart Antibodies | >80 publications with APOC2 and Heart |
| Kidney Antibodies | >30 publications with APOC2 and Kidney |
| Intestine Antibodies | >27 publications with APOC2 and Intestine |
| Lung Antibodies | >21 publications with APOC2 and Lung |
| Brain Antibodies | >17 publications with APOC2 and Brain |
| Skin Antibodies | >7 publications with APOC2 and Skin |
| Ovary Antibodies | >7 publications with APOC2 and Ovary |
| Embryonic Tissue Antibodies | >6 publications with APOC2 and Embryonic Tissue |
| Eye Antibodies | >5 publications with APOC2 and Eye |