Biotin-Linked Polyclonal Antibody to Lamin B1 (LMNB1)
Référence MBS2096005-0,2mL
Conditionnement : 0.2mL
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Lamin B1 (LMNB1) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2096005SPECIAL PROMOTION: Get FREE Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment
MBS2096005 is an antibody targeting LMNB1. Also known as Biotin-Linked Polyclonal Antibody to Lamin B1 (LMNB1). Reactive in Human, Mouse, Rat, Dog, Pig, Bovine, Goat, Horse. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
Lamin B1 (LMNB1), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Lamin B1 (LMNB1)
Product Gene Name
anti-LMNB1 antibody
Product Synonym Names
LMN; LMN2; LMNB
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Dog, Pig, Bovine, Goat, Horse
Concentration
500ug/ml (lot specific)
Matching Pairs
Unconjugated Antibody: LMNB1 (MBS2027031)
Biotin Conjugated Antibody: LMNB1 (MBS2096005)
Biotin Conjugated Antibody: LMNB1 (MBS2096005)
Matching Pairs
Biotin Conjugated Antibody: LMNB1 (MBS2096005)
Immunogen: LMNB1 (MBS2031124)
Immunogen: LMNB1 (MBS2031124)
Molecular Weight
66,408 Da
OMIM
M34458 mRNA
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Conjugation
Biotin
Cross Reactivity
Human, Pig
Immunogen
LMNB1 (Ser52~Gly233)
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-LMNB1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Other Notes
Small volumes of anti-LMNB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for LMNB1. It may not necessarily be applicable to this product.
NCBI Official Full Name
Lamin B1
NCBI Official Synonym Full Names
lamin B1
NCBI Official Symbol
LMNB1
NCBI Official Synonym Symbols
LMN; ADLD; LMN2; LMNB
UniProt Protein Name
Lamin-B1
Protein Family
Lamin
UniProt Gene Name
LMNB1
UniProt Synonym Gene Names
LMN2; LMNB
NCBI Protein Information
lamin-B1
NCBI Summary for LMNB1
This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
UniProt Comments for LMNB1
Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: lamin filament; membrane; nuclear envelope; nuclear inner membrane; nuclear matrix; nuclear membrane; nucleoplasm; nucleus
Molecular Function: phospholipase binding; protein binding; structural molecule activity
Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant
Show more Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5q23.2
Cellular Component: lamin filament; membrane; nuclear envelope; nuclear inner membrane; nuclear matrix; nuclear membrane; nucleoplasm; nucleus
Molecular Function: phospholipase binding; protein binding; structural molecule activity
Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-LMNB1 antibody
| Reference Product | PubMed Publications |
|---|---|
| LMNA antibody | >11 publications with LMNB1 and LMNA |
| LMNB2 antibody | >9 publications with LMNB1 and LMNB2 |
| SYNE1 antibody | >1 publications with LMNB1 and SYNE1 |
| BRCA1 antibody | >1 publications with LMNB1 and BRCA1 |
| CDK1 antibody | >1 publications with LMNB1 and CDK1 |
Pathways associated with anti-LMNB1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Apoptotic Cleavage Of Cellular Proteins Pathway antibodies | Apoptotic Cleavage Of Cellular Proteins Pathway Diagram |
| Apoptotic Execution Phase Pathway antibodies | Apoptotic Execution Phase Pathway Diagram |
| Breakdown Of The Nuclear Lamina Pathway antibodies | Breakdown Of The Nuclear Lamina Pathway Diagram |
| Caspase Cascade In Apoptosis Pathway antibodies | Caspase Cascade In Apoptosis Pathway Diagram |
| Cell Cycle Pathway antibodies | Cell Cycle Pathway Diagram |
| Cell Cycle, Mitotic Pathway antibodies | Cell Cycle, Mitotic Pathway Diagram |
| Chromosome Maintenance Pathway antibodies | Chromosome Maintenance Pathway Diagram |
| Clearance Of Nuclear Envelope Membranes From Chromatin Pathway antibodies | Clearance Of Nuclear Envelope Membranes From Chromatin Pathway Diagram |
| FAS Pathway And Stress Induction Of HSP Regulation antibodies | FAS Pathway And Stress Induction Of HSP Regulation Diagram |
Diseases associated with anti-LMNB1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Nervous System Diseases Antibodies | >15 publications with LMNB1 and Nervous System Diseases |
| Brain Diseases Antibodies | >9 publications with LMNB1 and Brain Diseases |
| Neoplasms Antibodies | >8 publications with LMNB1 and Neoplasms |
| Carcinoma Antibodies | >5 publications with LMNB1 and Carcinoma |
| Liver Diseases Antibodies | >4 publications with LMNB1 and Liver Diseases |
| Carcinoma, Hepatocellular Antibodies | >3 publications with LMNB1 and Carcinoma, Hepatocellular |
| Liver Neoplasms Antibodies | >3 publications with LMNB1 and Liver Neoplasms |
| Pelizaeus-Merzbacher Disease Antibodies | >3 publications with LMNB1 and Pelizaeus-Merzbacher Disease |
| Cardiomyopathies Antibodies | >2 publications with LMNB1 and Cardiomyopathies |
| Nervous System Malformations Antibodies | >2 publications with LMNB1 and Nervous System Malformations |
Organs/Tissues associated with anti-LMNB1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >7 publications with LMNB1 and Blood |
| Skin Antibodies | >5 publications with LMNB1 and Skin |
| Brain Antibodies | >5 publications with LMNB1 and Brain |
| Liver Antibodies | >4 publications with LMNB1 and Liver |
| Bone Antibodies | >3 publications with LMNB1 and Bone |
| Muscle Antibodies | >2 publications with LMNB1 and Muscle |
| Kidney Antibodies | >1 publications with LMNB1 and Kidney |
| Lung Antibodies | >1 publications with LMNB1 and Lung |
| Intestine Antibodies | >1 publications with LMNB1 and Intestine |
| Connective Tissue Antibodies | >1 publications with LMNB1 and Connective Tissue |