Carboxin [5234-68-4]
Référence T5559-100mg
Conditionnement : 100mg
Marque : TargetMol
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Carboxin
(Synonyms: Vitavax, Kisvax, Carboxine, Carbathiin) Copy Product Info
Carboxin (Kisvax) appears as off-white crystals. Systemic fungicide and seed protectant.
Cas No. 5234-68-4
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.52%
Appearance:Solid
Color:White
COA HNMR LCMS
Product Introduction
Carboxin AI Summary
Carboxin exhibits a variety of bioactivities across different biological systems and organisms. It shows potency in modulating miRNAs, lipid storage in Drosophila cells, inhibiting the ERK signaling pathway, HADH2, and miR-21, as well as inhibiting Nrf2, histone lysine methyltransferase G9a, HP1-beta chromodomain interactions, peroxisome proliferator-activated receptor delta signaling, DNA re-replication in colon adenocarcinoma cells, and human tyrosyl-DNA phosphodiesterase 1 (TDP1). The compound also activates the human pregnane X receptor (PXR) and antioxidant response element (ARE) signaling pathways and serves as an agonist for cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1), Aryl hydrocarbon Receptor (AhR) signaling pathway, and rat pregnane X receptor (rPXR) signaling pathway. Additionally, it has demonstrated delayed death inhibition of the malarial parasite and activity against firefly luciferase. Carboxin shows significant antiviral activity against SARS-CoV-2 with an IC50 value greater than 20000.0 nM, exhibiting moderate potency. It also possesses antifungal activity against Fusarium graminearum and Fusarium oxysporum, with growth inhibition of 56.3% and 23.6%, respectively, at 100 µg/ml. Its antifungal efficacy extends to controlling wheat leaf rust disease caused by Puccinia recondita with 100% efficacy at 50 µg/ml and 43.0% at 20 µg/ml, and fungicidal activity against Oculimacula yallundae with an EC50 value of 2.5 µg/ml. In terms of antiparasitic activity, Carboxin is effective against the Chagas Disease parasite Trypanosoma cruzi with an IC50 value of 22410.0 nM and an IC90 value of 57500.0 nM, showing no cytotoxicity against L-6 rat myoblasts up to 100000.0 nM. Additionally, it exhibits bioactivities related to resistance in sterol 14alpha-demethylation inhibitor-resistant strains of Oculimacula yallundae..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Carboxin (Kisvax) appears as off-white crystals. Systemic fungicide and seed protectant. |
| Synonyms | Vitavax, Kisvax, Carboxine, Carbathiin |
| Molecular Weight | 235.30 |
| Formula | C12H13NO2S |
| Cas No. | 5234-68-4 |
| Smiles | CC1=C(SCCO1)C(=O)NC1=CC=CC=C1 |
| Relative Density. | 1.45 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 47 mg/mL (199.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.5 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||