CD11b Polyclonal Antibody PE-Cy7 Conjugated
Référence MBS9462418-0,1mL
Conditionnement : 0.1mL
Marque : MyBiosource
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CD11b Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9462418MBS9462418 is an antibody targeting CD11b. Also known as CD11b Polyclonal Antibody PE-Cy7 Conjugated. Reactive in Human, Mouse, Rat. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
CD11b, Polyclonal Antibody
Full Product Name
CD11b Polyclonal Antibody PE-Cy7 Conjugated
Product Gene Name
anti-CD11b antibody
Product Synonym Names
CD11b
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Purity/Purification
affinity purified by Protein A
Preparation and Storage
Store at -20 degree C for one year. Avoid repeated freeze/thaw cycles.
Applications Tested/Suitable for anti-CD11b antibody
Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-CD11b antibody
FC/FACS: 1:50-200
IF: 1:50-200
IF: 1:50-200
Other Notes
Small volumes of anti-CD11b antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CD11b. It may not necessarily be applicable to this product.
NCBI Official Full Name
integrin alpha-M isoform 1
NCBI Official Synonym Full Names
integrin, alpha M (complement component 3 receptor 3 subunit)
NCBI Official Symbol
ITGAM
NCBI Official Synonym Symbols
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
UniProt Protein Name
Integrin alpha-M
UniProt Synonym Protein Names
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor
Protein Family
Integrin
UniProt Gene Name
ITGAM
UniProt Synonym Gene Names
CD11B; CR3A
UniProt Entry Name
ITAM_HUMAN
NCBI Protein Information
integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subuni
NCBI Summary for CD11b
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Show more UniProt Comments for CD11b
ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; plasma membrane; integrin complex; nucleus; external side of plasma membrane
Molecular Function: heparan sulfate proteoglycan binding; heparin binding; protein binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding
Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; toll-like receptor 4 signaling pathway; leukocyte migration
Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
Show more Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; plasma membrane; integrin complex; nucleus; external side of plasma membrane
Molecular Function: heparan sulfate proteoglycan binding; heparin binding; protein binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding
Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; toll-like receptor 4 signaling pathway; leukocyte migration
Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CD11b antibody
| Reference Product | PubMed Publications |
|---|---|
| ITGB2 antibody | >1633 publications with CD11b and ITGB2 |
| ICAM1 antibody | >436 publications with CD11b and ICAM1 |
| ICAM2 antibody | >20 publications with CD11b and ICAM2 |
| PLAUR antibody | >14 publications with CD11b and PLAUR |
| THY1 antibody | >14 publications with CD11b and THY1 |
| ICAM4 antibody | >6 publications with CD11b and ICAM4 |
| SELP antibody | >6 publications with CD11b and SELP |
| JAM3 antibody | >5 publications with CD11b and JAM3 |
Pathways associated with anti-CD11b antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Amoebiasis Pathway antibodies | Amoebiasis Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cell Surface Interactions At The Vascular Wall Pathway antibodies | Cell Surface Interactions At The Vascular Wall Pathway Diagram |
| Extracellular Matrix Organization Pathway antibodies | Extracellular Matrix Organization Pathway Diagram |
| Focal Adhesion Pathway antibodies | Focal Adhesion Pathway Diagram |
| Hematopoietic Cell Lineage Pathway antibodies | Hematopoietic Cell Lineage Pathway Diagram |
| Hematopoietic Cell Lineage Pathway antibodies | Hematopoietic Cell Lineage Pathway Diagram |
| Hemostasis Pathway antibodies | Hemostasis Pathway Diagram |
Diseases associated with anti-CD11b antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >1356 publications with CD11b and Inflammation |
| Neoplasms Antibodies | >924 publications with CD11b and Neoplasms |
| Necrosis Antibodies | >804 publications with CD11b and Necrosis |
| Disease Models, Animal Antibodies | >780 publications with CD11b and Disease Models, Animal |
| Nervous System Diseases Antibodies | >605 publications with CD11b and Nervous System Diseases |
| Cardiovascular Diseases Antibodies | >489 publications with CD11b and Cardiovascular Diseases |
| Brain Diseases Antibodies | >412 publications with CD11b and Brain Diseases |
| Neoplasms, Experimental Antibodies | >174 publications with CD11b and Neoplasms, Experimental |
| Heart Diseases Antibodies | >152 publications with CD11b and Heart Diseases |
| Pain Antibodies | >121 publications with CD11b and Pain |
Organs/Tissues associated with anti-CD11b antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >4389 publications with CD11b and Blood |
| Bone Antibodies | >815 publications with CD11b and Bone |
| Bone Marrow Antibodies | >758 publications with CD11b and Bone Marrow |
| Brain Antibodies | >601 publications with CD11b and Brain |
| Lung Antibodies | >516 publications with CD11b and Lung |
| Spleen Antibodies | >500 publications with CD11b and Spleen |
| Lymph Node Antibodies | >298 publications with CD11b and Lymph Node |
| Nerve Antibodies | >234 publications with CD11b and Nerve |
| Intestine Antibodies | >151 publications with CD11b and Intestine |
| Kidney Antibodies | >138 publications with CD11b and Kidney |