CD209 Antibody
Référence OAEE00725
Conditionnement : 100tests(T100)
Marque : Aviva Systems Biology
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| Datasheets/Manuals | Printable datasheet for CD209 Antibody |
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| Predicted Species Reactivity | Human |
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| Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Clonality | Monoclonal |
| Clone | UW60.1 |
| Isotype | IgG1 |
| Host | Mouse |
| Conjugation | APC |
| Application | FC |
| Reconstitution and Storage | 2°C to 8°C |
| Immunogen | CD209-His-tagged fusion protein |
| Purification | Purified by size-exclusion chromatography |
| Concentration | 10 ul / test |
| Specificity | The mouse monoclonal antibody UW60.1 recognizes human CD209 (DC-SIGN), a 44 kDa transmembrane receptor expressed on the surface of dendritic cells and macrophages. |
| Formulation | APC |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
| Reference | Ryan EJ, Marshall AJ, Magaletti D, Floyd H, Draves KE, Olson NE, Clark EA: Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4. J Immunol. 2002 Nov 15;169(10):5638-48. Geijtenbeek TB, Engering A, Van Kooyk Y: DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J Leukoc Biol. 2002 Jun;71(6):921-31. van Kooyk Y, Geijtenbeek TB: A novel adhesion pathway that regulates dendritic cell trafficking and T cell interactions. Immunol Rev. 2002 Aug;186:47-56. Khoo US, Chan KY, Chan VS, Lin CL: DC-SIGN and L-SIGN: the SIGNs for infection. J Mol Med. 2008 Aug;86(8):861-74. |
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| Gene Symbol | CD209 |
| Gene Full Name | CD209 molecule |
| Alias Symbols | C-type lectin domain family 4 member L, CD209 antigen, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, dendritic cell-specific ICAM-3-grabbing non-integrin 1, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin, dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin, hDC-SIGN, HIV gpl20-binding protein. |
| NCBI Gene Id | 30835 |
| Protein Name | CD209 antigen |
| Description of Target | Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. |
| Uniprot ID | Q9NNX6 |
| Protein Accession # | NP_001138365.1; NP_001138366.1; NP_001138367.1; NP_001138368.1; NP_001138369.1; NP_066978.1 |
| Nucleotide Accession # | NM_001144893.1; NM_001144894.1; NM_001144895.1; NM_001144896.1; NM_001144897.1; NM_021155.3 |
