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> CD41, CD61 (CD41b, GP2B, GP-IIb, GPIIb, GP3A, GP-IIIa, GPIIIa, GTA, HPA3, Integrin alpha 2b, ITGA2B, Integrin beta 3, ITGB3, Platelet Glycoprotein IIb of IIb/IIIa Complex) (APC)

CD41, CD61 (CD41b, GP2B, GP-IIb, GPIIb, GP3A, GP-IIIa, GPIIIa, GTA, HPA3, Integrin alpha 2b, ITGA2B, Integrin beta 3, ITGB3, Platelet Glycoprotein IIb of IIb/IIIa Complex) (APC)

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Référence C2394-35B-APC-100ul

Conditionnement : 100ul

Marque : US Biological

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Téléphone : +1 850 650 7790

C2394-35B-APCCD41, CD61 (CD41b, GP2B, GP-IIb, GPIIb, GP3A, GP-IIIa, GPIIIa, GTA, HPA3, Integrin alpha 2b, ITGA2B, Integrin beta 3, ITGB3, Platelet Glycoprotein IIb of IIb/IIIa Complex) (APC)

Specifications
Clone TypeMonoclonal
Hostmouse
Sourcechicken
IsotypeIgG1
GradeAffinity Purified
ApplicationsFC IF IP
CrossreactivityCh
Shipping TempBlue Ice
Storage Temp4°C Do Not Freeze

CD41/61 is a heterodimeric cell surface protein that is expressed on chicken thrombocytes and cells of the thrombocyte lineage. Avian thrombocytes are nucleated equivalents of mammalian platelets that play a role in coagulation and phagocytosis.

Applications:
Suitable for use in Flow Cytometry, Immunofluorescence and Immunoprecipitation. Other applications not tested.

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Hybridoma:
X63/A63-653 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Note: Applications are based on unconjugated antibody.

Applications
Product Type: Mab|Isotype: IgG1|Clone No: 10B1565 (11C3)|Host: mouse|Source: chicken|Concentration: As Reported|Form: Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).|Purity: Purified by Protein G affinity chromatography from tissue culture supernatant.|Immunogen: Peripheral blood leukocytes from white leghorn chicken.|Specificity: Recognizes the chicken integrin CD41/61. Reported to induce thrombocyte activation.||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Peripheral blood leukocytes from white leghorn chicken.
Form
Supplied as a liquid in PBS, pH 7.2. Labeled with Allophycocyanin (APC).
Purity
Purified by Protein G affinity chromatography from tissue culture supernatant.
Specificity
Recognizes the chicken integrin CD41/61. Reported to induce thrombocyte activation.
References
1. Lacoste-Eleaume, A.S. et al. (1994) Biochemical and functional characterization of an Avian homolog of the integrin GPIIb-IIa present on chicken thrombocytes. Exp. Cell. Res. 213: 198 - 209. 2. Corbel, C. et al. (2002) Expression of alpha V beta 3 integrin in the chick embryo aortic endothelium. Int. J. Dev. 46: 827 - 830. 3. Del Cacho, E. et al. (2008) Isolation of chicken follicular dendritic cells. J Immunol Methods. 334: 59-69. 4. Del Cacho, E. et al. (2009) Avian follicular and interdigitating dendritic cells: isolation and morphologic, phenotypic, and functional analyses. Vet Immunol Immunopathol. 129: 66-75. 5. Ody, C. et al. (1999) Glycoprotein IIb-IIIa is expressed on avian multilineage hematopoietic progenitor cells. Blood. 93: 2898-906. 6. Chaussé, A.M. et al. (2011) Expression of Toll-like receptor 4 and downstream effectors in selected cecal cell subpopulations of chicks resistant or susceptible to Salmonella carrier state. Infect Immun. 79: 3445-54.