CD49d (Integrin alpha4, VLA4, LHR, Lymphocyte Homing Receptor) (Biotin)
Référence MBS6242675-0,1mL
Conditionnement : 0.1mL
Marque : MyBiosource
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CD49d Antibody – Mouse Monoclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6242675MBS6242675 is an antibody targeting CD49d. Also known as CD49d (Integrin alpha4, VLA4, LHR, Lymphocyte Homing Receptor) (Biotin). Reactive in Human, Monkey, Porcine, Rat. Host: Mouse. More details
Product Overview
Online Datasheet in PDFProduct Name
CD49d, Monoclonal Antibody
Full Product Name
CD49d (Integrin alpha4, VLA4, LHR, Lymphocyte Homing Receptor) (Biotin)
Product Gene Name
anti-CD49d antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2Q981
Host
Mouse
Species Reactivity
Human, Monkey, Porcine, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified Ig fraction
Specificity
Recognizes the 80kD alpha chain of VLA-4. Reacts with monocytes, T-cells, B cells, thymocytes and Langerhans cells. Can be used in basic studies of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure. HP2/1 inhibits cell binding to soluble VCAM-1. Species Crossreactivity: Rat, porcine, rhesus monkey.
Preparation and Storage
Store at -20 degree C.
Applications Tested/Suitable for anti-CD49d antibody
Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Product References and Citations for anti-CD49d antibody
1. Sanchez-Madrid, F. et al. (1986). Eur. Journal Immunology 16: 1343-1349. 2 Weller et al. (1991). P.N.A.S. USA 88: 7430. 3.Mattila, P. et al. (1992). Int. J. Cancer 52: 918-923. 4.Leukocyte Typing Workshop V, p. 1646-1648
Other Notes
Small volumes of anti-CD49d antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for CD49d. It may not necessarily be applicable to this product.
NCBI Official Full Name
Integrin alpha-4
NCBI Official Synonym Full Names
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
NCBI Official Symbol
ITGA4
NCBI Official Synonym Symbols
IA4; CD49D
UniProt Protein Name
Integrin alpha-4
UniProt Synonym Protein Names
CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen: CD49d
Protein Family
Integrin
UniProt Gene Name
ITGA4
UniProt Synonym Gene Names
CD49D
UniProt Entry Name
ITA4_HUMAN
NCBI Protein Information
integrin alpha-4; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; very late activation protein 4 receptor, alpha 4 sub
NCBI Summary for CD49d
The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]
Show more UniProt Comments for CD49d
ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q31.3
Cellular Component: focal adhesion; cell surface; membrane; plasma membrane; intercellular junction; external side of plasma membrane
Molecular Function: protein binding; fibronectin binding; metal ion binding; cell adhesion molecule binding
Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; heart development; cell-matrix adhesion; receptor clustering; heterophilic cell adhesion; heterotypic cell-cell adhesion; leukocyte adhesion; B cell differentiation; blood vessel remodeling; blood coagulation; leukocyte tethering or rolling; leukocyte migration
Show more Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Receptor, misc.
Chromosomal Location of Human Ortholog: 2q31.3
Cellular Component: focal adhesion; cell surface; membrane; plasma membrane; intercellular junction; external side of plasma membrane
Molecular Function: protein binding; fibronectin binding; metal ion binding; cell adhesion molecule binding
Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; heart development; cell-matrix adhesion; receptor clustering; heterophilic cell adhesion; heterotypic cell-cell adhesion; leukocyte adhesion; B cell differentiation; blood vessel remodeling; blood coagulation; leukocyte tethering or rolling; leukocyte migration
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CD49d antibody
| Reference Product | PubMed Publications |
|---|---|
| MADCAM1 antibody | >49 publications with CD49d and MADCAM1 |
| PXN antibody | >15 publications with CD49d and PXN |
| ITGB1 antibody | >12 publications with CD49d and ITGB1 |
| VCAM1 antibody | >10 publications with CD49d and VCAM1 |
| ITGB7 antibody | >3 publications with CD49d and ITGB7 |
| CD81 antibody | >2 publications with CD49d and CD81 |
| FN1 antibody | >2 publications with CD49d and FN1 |
| ADAM28 antibody | >1 publications with CD49d and ADAM28 |
Pathways associated with anti-CD49d antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Adaptive Immune System Pathway antibodies | Adaptive Immune System Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram |
| Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies | Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cell Adhesion Molecules (CAMs) Pathway antibodies | Cell Adhesion Molecules (CAMs) Pathway Diagram |
| Cell Surface Interactions At The Vascular Wall Pathway antibodies | Cell Surface Interactions At The Vascular Wall Pathway Diagram |
| Dilated Cardiomyopathy Pathway antibodies | Dilated Cardiomyopathy Pathway Diagram |
| Dilated Cardiomyopathy Pathway antibodies | Dilated Cardiomyopathy Pathway Diagram |
| ECM-receptor Interaction Pathway antibodies | ECM-receptor Interaction Pathway Diagram |
Diseases associated with anti-CD49d antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >244 publications with CD49d and Inflammation |
| Demyelinating Diseases Antibodies | >183 publications with CD49d and Demyelinating Diseases |
| Disease Models, Animal Antibodies | >132 publications with CD49d and Disease Models, Animal |
| Central Nervous System Diseases Antibodies | >121 publications with CD49d and Central Nervous System Diseases |
| Necrosis Antibodies | >119 publications with CD49d and Necrosis |
| Lung Diseases Antibodies | >56 publications with CD49d and Lung Diseases |
| Leukemia, Lymphocytic, Chronic, B-Cell Antibodies | >34 publications with CD49d and Leukemia, Lymphocytic, Chronic, B-Cell |
| Atherosclerosis Antibodies | >21 publications with CD49d and Atherosclerosis |
| Lung Neoplasms Antibodies | >19 publications with CD49d and Lung Neoplasms |
| Liver Diseases Antibodies | >18 publications with CD49d and Liver Diseases |
Organs/Tissues associated with anti-CD49d antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >843 publications with CD49d and Blood |
| Vascular Antibodies | >475 publications with CD49d and Vascular |
| Bone Antibodies | >195 publications with CD49d and Bone |
| Bone Marrow Antibodies | >169 publications with CD49d and Bone Marrow |
| Brain Antibodies | >124 publications with CD49d and Brain |
| Lung Antibodies | >103 publications with CD49d and Lung |
| Embryonic Tissue Antibodies | >89 publications with CD49d and Embryonic Tissue |
| Lymph Antibodies | >84 publications with CD49d and Lymph |
| Lymph Node Antibodies | >84 publications with CD49d and Lymph Node |
| Muscle Antibodies | >76 publications with CD49d and Muscle |