Cordycepin [73-03-0]
Référence T2993-1ml
Conditionnement : 1mLx10mM(inDMSO)
Marque : TargetMol
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Cordycepin
(Synonyms: 3'-Deoxyadenosine) Copy Product Info
Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic derived from the fungus [Cordyceps militaris], exhibiting potential antineoplastic activity.
Cas No. 73-03-0
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.99%
Color:White
COA LCMS HNMR
Product Introduction
Cordycepin AI Summary
Cordycepin exhibits a diverse range of bioactivities across various pathogens and cellular systems. It demonstrates potent antiviral activity against Herpes Simplex Virus type-1 (HSV-1) in vero cells with an IC50 of 0.5 nM and other viruses including HSV-2, vaccinia virus, vesicular stomatitis virus, polio virus type 1, coxsackie B4 virus, parainfluenza virus type 3, reovirus type 1, sindbis virus, semliki forest virus, and HIV-1, with MIC values spanning from > 40.0 µg/mL to > 100.0 µg/mL. It inhibits Hepatitis C Virus (HCV) NS5B RNA synthesis at an IC50 of 22,000.0 nM and RNA replication at an EC50 of 46,000.0 nM, as well as cytopathic effects of HIV in MT-4 cells with an ED50 over 50.0 µM and cytotoxicity towards these cells at a CD50 of 45.0 µM. Additionally, Cordycepin shows a favorable selectivity for parasitic infections with an IC50 of 4.5 µg/mL for antimalarial activity, and displays trypanocidal activity with IC50 values ranging from 12.59 nM to 1122.02 nM depending on the assay. The compound is also active against Trypanosoma cruzi and Leishmania donovani. In terms of pharmacokinetics, oral administration of Cordycepin in C57BL/6 mice results in a Cmax of 10,100.0 nM, Tmax of 1.5 hours, AUC of 4824.0 ng.hr.mL^-1, and a half-life of 2.1 hours. It binds strongly to its target with a binding energy of -8.2 kCal mol^-1, shows affinity for the Adenosine A1 receptor with Ki values of 7120.0 nM without GTP and 15,200.0 nM with GTP (GTP shift of 2.1). Furthermore, it modulates PINK1 expression and inhibits multiple enzymes and cell line activities. Cordycepin also shows insufficient inhibition of SARS-CoV-2 cytotoxicity in specific assays and a weak inhibitory effect on the HDAC6 enzyme. Overall, these multifaceted activities underscore its potential therapeutic breadth, subject to further optimization for specificity and efficacy..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic derived from the fungus [Cordyceps militaris], exhibiting potential antineoplastic activity. |
| Synonyms | 3'-Deoxyadenosine |
| Molecular Weight | 251.24 |
| Formula | C10H13N5O3 |
| Cas No. | 73-03-0 |
| Smiles | Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)C[C@H]1O |
| Relative Density. | 1.2938 g/cm3 (Estimated) |
| Storage | Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25.63 mg/mL (102.01 mM), Sonication is recommended.  H2O: 8.29 mg/mL (33 mM), Sonication and heating are recommended. | ||||||||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.96 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||