CRFR2D Antibody
Référence MBS9208887-0,08mL
Conditionnement : 0.08mL
Marque : MyBiosource
CRFR2D (CRHR2) Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9208887Liaw et al. (1996) [PubMed 8536644] stated that there are 2 G protein-coupled corticotropin-releasing hormone (CRH; MIM 122560) receptors, CRHR1 (MIM 122561) and CRHR2, which they termed the CRF2 receptor. CRH is a 41-amino acid peptide synthesized in the… More details
Product Overview
Online Datasheet in PDFProduct Name
CRFR2D (CRHR2), Polyclonal Antibody
Full Product Name
CRFR2D Antibody
Product Gene Name
anti-CRHR2 antibody
Product Synonym Names
Corticotropin-releasing factor receptor 2; CRF-R-2; CRF-R2; CRFR-2; Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2; CRHR2; CRF2R; CRH2R
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This CRFR2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the human CRFR2D.
Preparation and Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CRFR2D peptide (MBS9218305) is used for blocking the activity of CRFR2D antibody (MBS9208887)
Molecular Weight
47688
OMIM
602034
Cellular Location
Cell membrane; Multi-pass membrane protein
Antigen Source
HUMAN
Function
G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Product Categories/Family for anti-CRHR2 antibody
Neuroscience; GPCR Antibodies
Applications Tested/Suitable for anti-CRHR2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-CRHR2 antibody
WB~~1:1000
IHC-P~~1:50 ~ 100
FC/FACS~~1:10 ~ 50
IHC-P~~1:50 ~ 100
FC/FACS~~1:10 ~ 50
Immunohistochemistry (IHC) of anti-CRHR2 antibody
CRFR2D Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CRFR2D Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product References and Citations for anti-CRHR2 antibody
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Gutknecht, E., et al. Eur. J. Pharmacol. 642 (1-3), 1-9 (2010) :
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Joubert, B.R., et al. Genome Med 2 (3), 17 (2010) :
Gutknecht, E., et al. Eur. J. Pharmacol. 642 (1-3), 1-9 (2010) :
Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Joubert, B.R., et al. Genome Med 2 (3), 17 (2010) :
Other Notes
Small volumes of anti-CRHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Searchable Terms for CRHR2 purchase
MBS9208887 is an antibody targeting CRHR2. Also known as CRFR2D Antibody. Reactive in Human. Host: Rabbit.
Additional Details
NCBI/Uniprot data below describe general gene information for CRHR2. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI Related Accession #
NCBI Official Full Name
corticotropin-releasing factor receptor 2 isoform 2
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 2
NCBI Official Symbol
CRHR2
NCBI Official Synonym Symbols
CRF2; CRFR2; CRF-RB; HM-CRF
UniProt Protein Name
Corticotropin-releasing factor receptor 2
UniProt Synonym Protein Names
Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2
Protein Family
Corticotropin-releasing factor receptor
UniProt Gene Name
CRHR2
UniProt Synonym Gene Names
CRF2R; CRH2R; CRF-R-2; CRF-R2; CRFR-2; CRH-R-2; CRH-R2
UniProt Entry Name
CRFR2_HUMAN
NCBI Protein Information
corticotropin-releasing factor receptor 2
NCBI Summary for CRHR2
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
Show more UniProt Comments for CRHR2
CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 2
Chromosomal Location of Human Ortholog: 7p14.3
Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; hormone activity; corticotrophin-releasing factor receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of angiogenesis
Show more Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 2
Chromosomal Location of Human Ortholog: 7p14.3
Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; hormone activity; corticotrophin-releasing factor receptor activity
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of angiogenesis
Research Articles on CRHR2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-CRHR2 antibody
| Reference Product | PubMed Publications |
|---|---|
| CRH antibody | >81 publications with CRHR2 and CRH |
| UCN antibody | >22 publications with CRHR2 and UCN |
| POMC antibody | >10 publications with CRHR2 and POMC |
| UCN2 antibody | >9 publications with CRHR2 and UCN2 |
| AVP antibody | >5 publications with CRHR2 and AVP |
Pathways associated with anti-CRHR2 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
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Diseases associated with anti-CRHR2 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Anxiety Disorders Antibodies | >13 publications with CRHR2 and Anxiety Disorders |
| Inflammation Antibodies | >9 publications with CRHR2 and Inflammation |
| Necrosis Antibodies | >7 publications with CRHR2 and Necrosis |
| Cardiovascular Diseases Antibodies | >7 publications with CRHR2 and Cardiovascular Diseases |
| Depressive Disorder Antibodies | >7 publications with CRHR2 and Depressive Disorder |
| Weight Loss Antibodies | >5 publications with CRHR2 and Weight Loss |
| Genital Diseases, Female Antibodies | >4 publications with CRHR2 and Genital Diseases, Female |
| Weight Gain Antibodies | >4 publications with CRHR2 and Weight Gain |
| Liver Diseases Antibodies | >3 publications with CRHR2 and Liver Diseases |
| Lung Diseases Antibodies | >3 publications with CRHR2 and Lung Diseases |
Organs/Tissues associated with anti-CRHR2 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Brain Antibodies | >52 publications with CRHR2 and Brain |
| Uterus Antibodies | >2 publications with CRHR2 and Uterus |
| Embryonic Tissue Antibodies | >2 publications with CRHR2 and Embryonic Tissue |
| Kidney Antibodies | >1 publications with CRHR2 and Kidney |
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