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Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.

DL-Mannitol [87-78-5]

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Référence NB-64-29182-1mL

Conditionnement : 1mLx10mM(inDMSO)

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DL-Mannitol

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Synonyms:

Catalog No. T4959 Copy Product Info

Purity: 99.95%

DL-Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake

Cas No. 87-78-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.95%

Appearance:Solid

Color:White

Product Information

DL-Mannitol AI Summary

DL-Mannitol is a highly hydrophilic antioxidant with a wide range of bioactivities and limited oral bioavailability in humans. It shows high cellular permeability (Pc) and moderate apparent permeability coefficient (Papp), displaying slightly biased transport from the apical to basal direction across Caco-2 cell monolayers. With a logP value of -3.1 and aqueous solubility indicated by a Log S value of 0.06, it demonstrates moderate water solubility, facilitating its distribution in biological systems. Despite its high permeability properties, compound 30180 has a low fraction absorbed (Fa) of 26.0% after oral administration and a relatively low oral bioavailability of 16.0%. In pharmacological activities, compound 30180 acts as an AOS scavenger and presents anti-arrhythmic properties in anesthetized rat models of ventricular fibrillation and tachycardia induced by ischemia-reperfusion. It also inhibits hydroxyl radical production with an IC50 value around 9600000.0 nM and has shown a 45.0% reduction in hydroxyl radical generation at 100 µg/mL. Moreover, it protects against photoirradiation-induced lipid peroxidation damage in rat liver mitochondria at a concentration of 100 mM. The compound exhibits moderate permeability in multiple models, including human Caco-2 cells and rat small intestine, and shows an antioxidant capacity through multiple assays. Furthermore, compound 30180 demonstrates a mild inhibition effect on DNA strand scission and protects against oxidative stress. The compound is also investigated for its potential effects on various receptors and enzymes but generally shows weak binding affinities with AC50 values greater than 30,000 nM. Overall, compound 30180 holds promise for further exploration as a therapeutic agent, especially in conditions related to oxidative stress and cardiac arrhythmias, although its low fraction absorbed and moderate oral bioavailability warrant additional optimization studies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	DL-Mannitol is a osmotic diuretic, it may play a role in reducing off-target 68Ga-PSMA renal uptake

Chemical Properties

Molecular Weight	182.17
Formula	C₆H₁₄O₆
Cas No.	87-78-5
Smiles	[C@H]([C@@H]([C@@H](CO)O)O)([C@@H](CO)O)O
Relative Density.	1.596 g/cm3

Storage & Solubility Information

Storage

Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (274.47 mM), Sonication is recommended.

DMSO: 27.5 mg/mL (150.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.76 mg/mL (15.15 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	5.4894 mL	27.4469 mL	54.8938 mL	274.4689 mL
5 mM	1.0979 mL	5.4894 mL	10.9788 mL	54.8938 mL
10 mM	0.5489 mL	2.7447 mL	5.4894 mL	27.4469 mL
20 mM	0.2745 mL	1.3723 mL	2.7447 mL	13.7234 mL
50 mM	0.1098 mL	0.5489 mL	1.0979 mL	5.4894 mL
100 mM	0.0549 mL	0.2745 mL	0.5489 mL	2.7447 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

DL-MannitolDLMannitolDL Mannitol

Related Tags: DL-Mannitol chemical structure | DL-Mannitol formula | DL-Mannitol molecular weight