EME1 Antibody
Référence MBS856095-0,1mL-AF647
Conditionnement : 0.1mL(AF647)
Marque : MyBiosource
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Western blot analysis of extracts from COLO cells, using EME1 antibody.
EME1 Antibody
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS856095MBS856095 is an antibody targeting EME1. Also known as EME1 Antibody. Reactive in Human. More details
Product Overview
Online Datasheet in PDFProduct Name
EME1, Antibody
Full Product Name
EME1 Antibody
Product Gene Name
anti-EME1 antibody
Product Synonym Names
Crossover junction endonuclease EME1; EME1; essential meiotic endonuclease 1 homolog 1 (S. pombe); essential meiotic endonuclease 1 homolog 2; FLJ31364; hMMS4; homolog of yeast EME1 endonuclease; MMS4; MMS4 homolog; MMS4L
Species Reactivity
Human
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Specificity
EME1 antibody detects endogenous levels of total EME1 protein.
Preparation and Storage
Store at-20 degree C for 1 year.
Molecular Weight
64,779 Da
OMIM
610885
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human EME1.
Product Categories/Family for anti-EME1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EME1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-EME1 antibody
WB: 1:500-1:1000
ELISA: 1:1000
ELISA: 1:1000
Product References and Citations for anti-EME1 antibody
Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039]. Zody M.C., Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract]. Oegruenc M., J. Biol. Chem. 278:21715-21720(2003) [PubMed: 12686547].
Other Notes
Small volumes of anti-EME1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for EME1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
crossover junction endonuclease EME1 isoform 1
NCBI Official Synonym Full Names
essential meiotic structure-specific endonuclease 1
NCBI Official Symbol
EME1
NCBI Official Synonym Symbols
MMS4L; SLX2A
UniProt Protein Name
Crossover junction endonuclease EME1
UniProt Synonym Protein Names
MMS4 homolog; hMMS4
Protein Family
Crossover junction endonuclease
UniProt Gene Name
EME1
UniProt Synonym Gene Names
MMS4; hMMS4
NCBI Protein Information
crossover junction endonuclease EME1
NCBI Summary for EME1
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Show more UniProt Comments for EME1
Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Show more Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-EME1 antibody
| Reference Product | PubMed Publications |
|---|---|
| MUS81 antibody | >77 publications with EME1 and MUS81 |
Pathways associated with anti-EME1 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Fanconi Anemia Pathway antibodies | Fanconi Anemia Pathway Diagram |
| Fanconi Anemia Pathway antibodies | Fanconi Anemia Pathway Diagram |
| Homologous Recombination Pathway antibodies | Homologous Recombination Pathway Diagram |
| Homologous Recombination Pathway antibodies | Homologous Recombination Pathway Diagram |
Diseases associated with anti-EME1 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Neoplasms Antibodies | >6 publications with EME1 and Neoplasms |
| Drug Hypersensitivity Antibodies | >3 publications with EME1 and Drug Hypersensitivity |
| Lymphoma Antibodies | >2 publications with EME1 and Lymphoma |
| Cell Transformation, Neoplastic Antibodies | >1 publications with EME1 and Cell Transformation, Neoplastic |
| Weight Gain Antibodies | >1 publications with EME1 and Weight Gain |
Organs/Tissues associated with anti-EME1 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >2 publications with EME1 and Blood |
| Bone Antibodies | >1 publications with EME1 and Bone |
| Intestine Antibodies | >1 publications with EME1 and Intestine |
| Brain Antibodies | >1 publications with EME1 and Brain |