Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> Ertapenem sodium [153773-82-1]

Ertapenem sodium [153773-82-1]

Imprimer Imprimer
Identifiez-vous

Référence HY-13625-50mg

Conditionnement : 50mg

Marque : MedChemExpress

Contactez votre distributeur local :


Téléphone : +1 850 650 7790

Description

Ertapenem sodium (L-749345) is a broad spectrum and long acting β-lactam antibiotic. Ertapenem sodium has a broad-spectrum anti-anaerobic activity against a variety of anaerobes with a mode MIC of 0.12 μg/mL. Ertapenem sodium can be used for the research of severe infections caused by bacteria in the skin, lungs, stomach, pelvis, and urinary tract[1][2].

IC50 & Target

β-lactam

 

In Vitro

Ertapenem sodium (0-100 μg/mL approximately, 48 h) is active against 99.1% of all anaerobes with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and MIC’s ≥8 μg/mL for B.fragilis and B.vulgatus species, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ertapenem sodium Related Antibodies

Cell Viability Assay[1]

Cell Line: B. fragilis (ATCC 25285), B. thetaiotaomicron (ATCC 29741), and Eubacterium lentum (ATCC 43055)
Concentration: 0-100 μg/mL approximately
Incubation Time: 48 h
Result: Inhibited 99.1% of all isolate with a mode MIC of 0.12 μg/mL and MIC90 of 1 μg/mL, and 98.8% of the isolates were susceptible among the B. fragilis group.
In Vivo

Ertapenem sodium (Subcutaneous injection, 0-10 mg/kg, 0-120 h after infection, S. aureus thigh tissue infection model) shows > 3 log10 CFU reduction of organism at 10 mg/kg, and maintains the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg[2].
Ertapenem sodium (Subcutaneous injection, 4h after infection, systemic infection model) is active against all gram-positive organisms, and is also active against gram-negative organisms tested with ED50s of <0.25 mg/kg/dose[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: S. aureus thigh tissue infection model (DBA/2 mice)[2]
Dosage: 0.5,1, 2, 5, 10 mg/kg (given at 2, 6, 10, 24, 48, 72, 96, 120 h)
Administration: Subcutaneous injection (0.5 mL after infection)
Result: Displayed > 3 log10 CFU reduction of organism compared to non-antibiotic-treated controls at 10 mg/kg.
Maintained the activity with 3.3 and 4.4 log10 CFU eliminated at 2 mg/kg.
Animal Model: Systemic infection model (DBA/2 female mice, viral antibody-free CD-1 female mice)[2]
Dosage: 0-3 mg/kg approximately
Administration: Subcutaneous injection (0.5 mL, begin immediately and 4 h after infection)
Result: Showed activity against all gram-positive organisms, and also ram-negative organisms tested with ED50s of <0.25 mg/kg/dose.
Animal Model: CD-1 mice, rats[2]
Dosage: 10 mg/kg approximately
Administration: Intraperitoneal injection (pharmacokinetic assay)
Result: Exhibited an AUC0-∞ ranging from 1.8-21.82 μg•hr/mL in tissue in mice following a 10-mg/kg i.p. dose.
Exhibited slow clearance rate with a t1/2β of 3.2 h, Clp of 0.47 mL/min/kg, AUC0-8 of 284.15 μg•hr/mL.
Essai clinique
Masse moléculaire

497.50

Formule

C22H24N3NaO7S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C([C@H]1NC[C@@H](SC2=C(C(O)=O)N3[C@]([C@]([C@@H](C)O)(17)C3=O)(17)[C@H]2C)C1)NC4=CC=CC(C(O[Na])=O)=C4
Livraison

Shipping with dry ice.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro: 

H2O : 50 mg/mL (100.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0101 mL 10.0503 mL 20.1005 mL
5 mM 0.4020 mL 2.0101 mL 4.0201 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (201.01 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureté et documentation
Références

Vous serez peut-être également intéressé par les produits suivants :



Référence
Description
Cond.
Prix HT
Promotion
CSB-E08590r-96T
Rat Serum amyloid A,SAA ELISA Kit
 96T 
HY-17373-10mg
Posaconazole [171228-49-2]
 10mg