Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> Guaiacol [90-05-1]

Guaiacol [90-05-1]

Imprimer Imprimer
Identifiez-vous

Référence orb1223711-500mg

Conditionnement : 500mg

Marque : Biorbyt

Contactez votre distributeur local :


Téléphone : +1 850 650 7790

Guaiacol

SKU: orb1223711

Description

Guaiacol is a precursor to various flavorants, such as eugenol and vanillin. Its derivatives are used medicinally as an expectorant, antiseptic, and local anesthetic. It also can be used as an indicator in chemical reactions that produce oxygen. When oxygen binds to it, the complex turns yellowish brown and absorbs light maximally at about 470 nm.(In Vitro):Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-κB) activation and cyclooxygenase (COX)-2 gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such as Phenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, as indicated by their 50% inhibition concentrations, which decline in the following order: Phenol (1600 μM) > Vanillin (>500 μM) > Guaiacol (72 μM) > Eugenol (12 μM).

Research Area

Pharmacology & Drug Discovery

Images & Validation

−
Guaiacol

Key Properties

−
CAS Number90-05-1
MW124.14
Purity>98% (HPLC)
FormulaC7H8O2
SMILESCOC1=CC=CC=C1O
TargetOthers
SolubilityDMSO: 10 mM

Bioactivity

−
In Vitro
Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-κB) activation and cyclooxygenase (COX)-2 gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such as Phenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, as indicated by their 50% inhibition concentrations, which decline in the following order: Phenol (1600 μM) > Vanillin (>500 μM) > Guaiacol (72 μM) > Eugenol (12 μM).

Storage & Handling

−
StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
−
  • Horseradish Peroxidase

    Horseradish Peroxidase [orb3073127]

    >90%

    Microorganism

    100 U, 1 ku, 10 ku
  • Guacetisal

    Guacetisal [orb1308242]

    99.18% (May vary between batches)

    55482-89-8

    286.28

    C16H14O5

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 1 ml x 10 mM (in DMSO)
  • Vanillyl Alcohol

    Vanillyl Alcohol [orb1304919]

    >99.99% (May vary between batches)

    498-00-0

    154.16

    C8H10O3

    1 ml x 10 mM (in DMSO), 1 g
  • Guaiacol Carbonate

    Guaiacol Carbonate [orb1909013]

    553-17-3

    274.27

    C15H14O5

    25 mg
  • Guaifenesin

    Guaifenesin [orb1310335]

    >99.99% (May vary between batches)

    93-14-1

    198.22

    C10H14O4

    1 g, 1 ml x 10 mM (in DMSO)

Quick Database Links

Gene Symbol
Others

Protocol Information