Human IFN-lambda-1 (Animal Free)
Référence MBS692906-0,005mg
Conditionnement : 0.005mg
Marque : MyBiosource
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IFN-lambda-1 Human Recombinant Protein
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS692906MBS692906 is a recombinant protein targeting IFN-lambda-1. Also known as Human IFN-lambda-1 (Animal Free). Host: E coli. More details
Product Overview
Online Datasheet in PDFProduct Name
IFN-lambda-1, Recombinant Protein
Full Product Name
Human IFN-lambda-1 (Animal Free)
Product Gene Name
IFN-lambda-1 recombinant protein
Product Synonym Names
IL29; IFNL1; IL-29; IL-29; IL-28A; IL-28B
Sequence
PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
Host
E coli
Form/Format
lyophilized
Purity/Purification
>= 98% by SDS-PAGE gel and HPLC analyses.
Molecular Weight
21,898 Da
OMIM
607403
Species
Human
Species Reactivity/Cross reactivity
Human, Monkey
Endotoxin level
<0.01 ng/ug of protein (<0.1 EU/ug)
Biological Activity
Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
Chromosomal Location
19q13.13
Product Categories/Family for IFN-lambda-1 recombinant protein
Cytokines & Growth Factors
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of IFN-lambda-1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for IFN-lambda-1. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interferon lambda-1
NCBI Official Synonym Full Names
interferon, lambda 1
NCBI Official Symbol
IFNL1
NCBI Official Synonym Symbols
IL29; IL-29
UniProt Protein Name
Interferon lambda-1
UniProt Synonym Protein Names
Cytokine Zcyto21; Interleukin-29
Protein Family
Interferon
UniProt Gene Name
IFNL1
UniProt Synonym Gene Names
IL29; ZCYTO21; IFN-lambda-1; IL-29
UniProt Entry Name
IFNL1_HUMAN
NCBI Protein Information
interferon lambda-1; IFN-lambda-1; interleukin-29; cytokine Zcyto21; interferon-lambda-1; interleukin 29 (interferon, lambda 1)
NCBI Summary for IFN-lambda-1
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Show more UniProt Comments for IFN-lambda-1
IL29: Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Belongs to the IL-28/IL-29 family.
Protein type: Cytokine; Secreted, signal peptide; Secreted; Cell cycle regulation
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex
Molecular Function: cytokine activity; interleukin-28 receptor binding; receptor binding
Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; positive regulation of interferon-gamma production; negative regulation of interleukin-13 production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of memory T cell differentiation; defense response to virus
Show more Protein type: Cytokine; Secreted, signal peptide; Secreted; Cell cycle regulation
Chromosomal Location of Human Ortholog: 19q13.13
Cellular Component: extracellular space; extracellular region; interleukin-28 receptor complex
Molecular Function: cytokine activity; interleukin-28 receptor binding; receptor binding
Biological Process: positive regulation of immune response; positive regulation of transcription, DNA-dependent; positive regulation of JAK-STAT cascade; JAK-STAT cascade; negative regulation of T cell differentiation; negative regulation of cell proliferation; positive regulation of interferon-gamma production; negative regulation of interleukin-13 production; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of T-helper 2 type immune response; negative regulation of interleukin-5 production; positive regulation of MHC class I biosynthetic process; negative regulation of transcription, DNA-dependent; negative regulation of memory T cell differentiation; defense response to virus
Research Articles on IFN-lambda-1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with IFN-lambda-1 recombinant protein
| Reference Product | PubMed Publications |
|---|---|
| TLR3 recombinant protein | >2 publications with IFN-lambda-1 and TLR3 |
Pathways associated with IFN-lambda-1 recombinant protein
| Products by Pathway | Pathway Diagram |
|---|---|
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Cytokine-cytokine Receptor Interaction Pathway antibodies | Cytokine-cytokine Receptor Interaction Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
| Jak-STAT Signaling Pathway antibodies | Jak-STAT Signaling Pathway Diagram |
| Type III Interferon Signaling Pathway antibodies | Type III Interferon Signaling Pathway Diagram |
Diseases associated with IFN-lambda-1 recombinant protein
| Disease Name | Pubmed Publications |
|---|---|
| Antibodies | >4 publications with IFN-lambda-1 and |