Human MAPK3/MAPK1 Antibody : APC (Phospho-Thr202/Tyr204)
Référence OAAQ00003-100tests
Conditionnement : 100Tests
Marque : Aviva Systems Biology
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Human MAPK3/MAPK1 Antibody : APC (Phospho-Thr202/Tyr204)
Human MAPK3/MAPK1 Antibody : APC (Phospho-Thr202/Tyr204) (OAAQ00003)
| Datasheets/Manuals | Printable datasheet for OAAQ00003 |
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| Tested Species Reactivity | Human, Mouse |
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| Predicted Species Reactivity | Mouse, Rat |
| Product Format | Liquid. 1X PBS, 0.09% NaN3, 0.2% BSA. |
| Clonality | Monoclonal |
| Clone | ERK12T202Y204-A11 |
| Isotype | Rabbit IgG1k |
| Host | Rabbit |
| Conjugation | APC: Allophycocyanin |
| Application | FC |
| Reconstitution and Storage | 2-8C |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Thr202/Tyr204 of human phospho Erk1/2. |
| Purification | Protein A+G |
| Target Post-Translational Modification | Phospho-Thr202/Tyr204 |
| Application Info | For flow cytometric staining, the suggested use of this reagent is 5 uL per million cells or 5 uL per 100 uL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Reference | Roskoski Jr R. (2012) Pharmacological Research. 66: 105-143. |
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| Gene Symbol | MAPK3, MAPK1 |
| Gene Full Name | mitogen-activated protein kinase 3, mitogen-activated protein kinase 1 |
| Alias Symbols | ERK1, ERT2, ERK-1, PRKM3, P44ERK1, P44MAPK, HS44KDAP, HUMKER1A, p44-ERK1, p44-MAPK |
| NCBI Gene Id | 5595; 5594 |
| Protein Name | mitogen-activated protein kinase 3, mitogen-activated protein kinase 1 |
| Description of Target | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. |
| Uniprot ID | P27361, P28482 |
| Protein Accession # | NP_001035145.1 |
| Nucleotide Accession # | NM_001040056.2 |
