IMPDH2 Antibody - C-terminal region - HRP
Référence ARP54366_P050-HRP
Conditionnement : 100ul
Marque : Aviva Systems Biology
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IMPDH2 Antibody - C-terminal region : HRP (ARP54366_P050-HRP)
| Datasheets/Manuals | Printable datasheet for anti-IMPDH2 (ARP54366_P050-HRP) antibody |
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| Predicted Species Reactivity | Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish |
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| Product Format | Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Conjugation | HRP: Horseradish Peroxidase |
| Application | WB |
| Reconstitution and Storage | All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Immunogen | The immunogen is a synthetic peptide directed towards the C terminal region of human IMPDH2 |
| Purification | Affinity Purified |
| Predicted Homology Based on Immunogen Sequence | Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 92%; Zebrafish: 93% |
| Peptide Sequence | Synthetic peptide located within the following region: SCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF |
| Concentration | 0.5 mg/ml |
| Blocking Peptide | For anti-IMPDH2 (ARP54366_P050-HRP) antibody is Catalog # AAP54366 (Previous Catalog # AAPP31141) |
| Reference | Grinyo,J., (er) Transpl. Int. (2008) In press |
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| Gene Symbol | IMPDH2 |
| Gene Full Name | IMP (inosine 5'-monophosphate) dehydrogenase 2 |
| Alias Symbols | IMPD2, IMPDH-II |
| NCBI Gene Id | 3615 |
| Protein Name | Inosine-5'-monophosphate dehydrogenase 2 |
| Description of Target | IMPDH2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. It catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. IMPDH2 is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Uniprot ID | P12268 |
| Protein Accession # | NP_000875 |
| Nucleotide Accession # | NM_000884 |
| Protein Size (# AA) | 514 |
| Molecular Weight | 56kDa |
| Protein Interactions | RSG1; APIP; HUWE1; UBC; IMPDH2; CDK2; RPA1; RPA3; RPA2; PRKAR2A; IMPDH1; EIF2S3; PARK2; MAPK10; SOX2; NPM1; PEX14; FN1; RPLP0P6; RPS6; RPL15; FOLR1; FBXO6; GRB2; UBQLN4; PIAS4; COPS5; COPS6; CUL3; YWHAZ; FBXO25; SIRT7; HDAC5; MME; SUMO4; AKT1; IKBKE; ATG5 |
