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> Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

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Référence NB-64-58941-500ug

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Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)

(Synonyms: ITGAV & ITGB6, integrin, α5 (fibronectin receptor, α polypeptide), integrin, alpha 5 (fibronectin receptor, alpha polypeptide), Integrin α V β 6, Integrin alpha V β6) Copy Product Info

Synonyms: ITGAV & ITGB6, integrin, α5 (fibronectin receptor, α polypeptide), integrin, alpha 5 (fibronectin receptor, alpha polypeptide), Integrin α V β 6, Integrin alpha V β6

Catalog No. TMPY-03878 Copy Product Info
Purity: 96.6%
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
Other Forms of Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His):
Integrin alpha 5 beta 1 Protein, Human, Recombinant (Flag & His)
Integrin alpha V beta 6 Protein, Mouse, Recombinant (Flag & His)
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:96.6%
Appearance:Lyophilized powder
Color:White
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Product Introduction

Bioactivity
Bioactivity
Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with Flag and His tag. The predicted molecular weight is 190.4 kDa and the accession number is P06756-1&P18564-1.
Species
Human
Expression System
HEK293 Cells
TagC-Flag, C-His
Accession NumberP06756-1&P18564-1
ConstructionA DNA sequence encoding the extracellular domain (Met 1-Val992) of human ITGAV (P06756-1) was fused with a flag tag at the C-terminus, constructed the plasmid 1; A DNA sequence encoding the extracellular domain (Met1-Asn707) of human ITGB6 (P18564-1) was fused with a polyhistidine tag at the C-terminus, constructed the plasmid 2. The two plasmids were co-expressed and the human ITGAV&ITGB6 heterodimer was purified. Predicted N terminal: Phe 31 & Gly 22
Protein Purity
> 95 % as determined by SDS-PAGE
Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His)
Endotoxin< 1.0 EU/μg of the protein as determined by the LAL method.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
ReconstitutionReconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
SynonymsITGAV & ITGB6, integrin, α5 (fibronectin receptor, α polypeptide), integrin, alpha 5 (fibronectin receptor, alpha polypeptide), Integrin α V β 6, Integrin alpha V β6
Research Background
Integrin alpha-5, also known as ITGA5, is a single-pass type I membrane protein which belongs to the integrin alpha chain family. ITGA5 contains 7 FG-GAP repeats. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of ITGAV&ITGB6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
Chemical Properties
Molecular Weight190.4 kDa (predicted)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

integrin, α 5integrin, alpha 5integrin, a 5fibronectin receptor, α polypeptidefibronectin receptor, alpha polypeptidefibronectin receptor, a polypeptide
Related Tags: Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) chemical structure | Integrin alpha V beta 6 Protein, Human, Recombinant (Flag & His) molecular weight