IRF3 Antibody
Référence MBS8582780-0,1mL-AF647
Conditionnement : 0.1mL(AF647)
Marque : MyBiosource
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IRF3 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8582780MBS8582780 is an antibody targeting IRF3. Also known as IRF3 Antibody. Reactive in Human, Bovine, Pig. Host: Rabbit. Rabbit polyclonal antibody to IRF3 More details
Product Overview
Online Datasheet in PDFProduct Name
IRF3, Polyclonal Antibody
Full Product Name
IRF3 Antibody
Product Gene Name
anti-IRF3 antibody
Product Synonym Names
Interferon regulatory factor 3; IRF-3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Bovine, Pig
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH7.3, 30% glycerol, and 0.01% sodium azide.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Specificity
Recognizes endogenous levels of IRF3 protein.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Molecular Weight
47,219 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (50162826..50169132, complement). Location: 19q13.3-q13.4
OMIM
603734
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human IRF3. The exact sequence is proprietary.
Product Categories/Family for anti-IRF3 antibody
Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-IRF3 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
Application Notes for anti-IRF3 antibody
WB: 1:500-1:1000
IHC: 1:50-1:200
IHC: 1:50-1:200
Other Notes
Small volumes of anti-IRF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for IRF3. It may not necessarily be applicable to this product.
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
interferon regulatory factor 3 isoform 4
NCBI Official Synonym Full Names
interferon regulatory factor 3
NCBI Official Symbol
IRF3
UniProt Protein Name
Interferon regulatory factor 3
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF3
UniProt Synonym Gene Names
IRF-3
UniProt Entry Name
IRF3_HUMAN
NCBI Protein Information
interferon regulatory factor 3
NCBI Summary for IRF3
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Show more UniProt Comments for IRF3
IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activity
Biological Process: negative regulation of interferon-beta biosynthetic process; transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; negative regulation of defense response to virus by host; response to exogenous dsRNA; positive regulation of interferon type I production; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-beta production; toll-like receptor signaling pathway; innate immune response; interferon type I biosynthetic process; toll-like receptor 4 signaling pathway; response to DNA damage stimulus; negative regulation of interferon type I production; defense response to virus; positive regulation of interferon-alpha production; positive regulation of cytokine secretion
Disease: Herpes Simplex Encephalitis, Susceptibility To, 7
Show more Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activity
Biological Process: negative regulation of interferon-beta biosynthetic process; transcription from RNA polymerase II promoter; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; negative regulation of defense response to virus by host; response to exogenous dsRNA; positive regulation of interferon type I production; lipopolysaccharide-mediated signaling pathway; positive regulation of interferon-beta production; toll-like receptor signaling pathway; innate immune response; interferon type I biosynthetic process; toll-like receptor 4 signaling pathway; response to DNA damage stimulus; negative regulation of interferon type I production; defense response to virus; positive regulation of interferon-alpha production; positive regulation of cytokine secretion
Disease: Herpes Simplex Encephalitis, Susceptibility To, 7
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-IRF3 antibody
| Reference Product | PubMed Publications |
|---|---|
| IRF7 antibody | >197 publications with IRF3 and IRF7 |
| TBK1 antibody | >166 publications with IRF3 and TBK1 |
| CXCL10 antibody | >43 publications with IRF3 and CXCL10 |
| IRF5 antibody | >34 publications with IRF3 and IRF5 |
| IKBKE antibody | >27 publications with IRF3 and IKBKE |
| RELA antibody | >21 publications with IRF3 and RELA |
| CREBBP antibody | >13 publications with IRF3 and CREBBP |
| EP300 antibody | >6 publications with IRF3 and EP300 |
| GRIP1 antibody | >3 publications with IRF3 and GRIP1 |
| PIAS4 antibody | >2 publications with IRF3 and PIAS4 |
Pathways associated with anti-IRF3 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Activated TLR4 Signalling Pathway antibodies | Activated TLR4 Signalling Pathway Diagram |
| Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies | Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram |
| Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies | Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram |
| Apoptosis Pathway antibodies | Apoptosis Pathway Diagram |
| Cytokine Signaling In Immune System Pathway antibodies | Cytokine Signaling In Immune System Pathway Diagram |
| Cytosolic DNA-sensing Pathway antibodies | Cytosolic DNA-sensing Pathway Diagram |
| Cytosolic DNA-sensing Pathway antibodies | Cytosolic DNA-sensing Pathway Diagram |
| Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies | Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram |
| DAI Mediated Induction Of Type I IFNs Pathway antibodies | DAI Mediated Induction Of Type I IFNs Pathway Diagram |
| Epstein-Barr Virus Infection Pathway antibodies | Epstein-Barr Virus Infection Pathway Diagram |
Diseases associated with anti-IRF3 antibody
| Disease Name | Pubmed Publications |
|---|---|
| Inflammation Antibodies | >144 publications with IRF3 and Inflammation |
| Necrosis Antibodies | >113 publications with IRF3 and Necrosis |
| Death Antibodies | >50 publications with IRF3 and Death |
| Neoplasms Antibodies | >48 publications with IRF3 and Neoplasms |
| Liver Diseases Antibodies | >44 publications with IRF3 and Liver Diseases |
| Cardiovascular Diseases Antibodies | >22 publications with IRF3 and Cardiovascular Diseases |
| Carcinoma Antibodies | >15 publications with IRF3 and Carcinoma |
| Kidney Diseases Antibodies | >14 publications with IRF3 and Kidney Diseases |
| Neoplasms, Experimental Antibodies | >9 publications with IRF3 and Neoplasms, Experimental |
| Drug Toxicity Antibodies | >7 publications with IRF3 and Drug Toxicity |
Organs/Tissues associated with anti-IRF3 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Blood Antibodies | >131 publications with IRF3 and Blood |
| Liver Antibodies | >50 publications with IRF3 and Liver |
| Bone Antibodies | >45 publications with IRF3 and Bone |
| Kidney Antibodies | >37 publications with IRF3 and Kidney |
| Lung Antibodies | >36 publications with IRF3 and Lung |
| Skin Antibodies | >22 publications with IRF3 and Skin |
| Brain Antibodies | >22 publications with IRF3 and Brain |
| Spleen Antibodies | >21 publications with IRF3 and Spleen |
| Vascular Antibodies | >17 publications with IRF3 and Vascular |
| Intestine Antibodies | >10 publications with IRF3 and Intestine |