Isoniazid [54-85-3]
Référence T0972-1ml
Conditionnement : 1mLx10mM(inDMSO)
Marque : TargetMol
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Isoniazid
(Synonyms: Isonicotinic hydrazide, Isonicotinic acid hydrazide, INH) Copy Product Info
Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic.
Cas No. 54-85-3
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.79%
Appearance:Solid
Color:White
COA LCMS HNMR
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Isoniazid (Isonicotinic hydrazide) is an antibacterial agent used primarily as a tuberculostatic. |
| In vitro | Isoniazid is a prodrug that requires activation by the mycobacterial catalase-peroxidase enzyme (KatG) to an active form that then exerts a lethal effect on an intracellular target or targets. [1] Isoniazid upregulates the expression of an operon containing five FAS II components, including kasA and acpM. Isoniazid results in the accumulation of ACP-bound lipid precursors to mycolic acids that are 26 carbons long and fully saturated. [2] Isoniazid enters the mycobacterial cell by passive diffusion. Isoniazid itself is not toxic to the bacterial cell, but acts as a prodrug and is activated by the mycobacterial enzyme KatG, a multifunctional catalase-peroxidase that has other activities, including peroxynitritase and NADH oxidase. Isoniazid inhibits cell wall lipid synthesis, coupled with the findings that inhibitory INH adducts of NAD+/NADP+ are formed from the isonicotinoyl radical, leading the field away from this area. [3] Isoniazid induces a concentration-dependent (0-40 mM) cytotoxic effect in day-1 treated HepG2 cells and not significantly affected by decreases in intracellular GSH concentrations. [4] |
| In vivo | Isoniazid increases CYP2E1 protein, and the 6-hydroxychlorzoxazone formation rate is increased by 2.7 and 2.2-fold in liver and kidney, respectively. Isoniazid decreases liver and kidney 20-HETE content to 34% and 15.6% of control, respectively, without significantly altering tissue 19-HETE concentration. [5] |
| Synonyms | Isonicotinic hydrazide, Isonicotinic acid hydrazide, INH |
| Molecular Weight | 137.14 |
| Formula | C6H7N3O |
| Cas No. | 54-85-3 |
| Smiles | NNC(=O)C1=CC=NC=C1 |
| Relative Density. | 1.244g/cm3 |
| Storage | Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60.63 mg/mL (442.1 mM), Sonication is recommended.  H2O: 25 mg/mL (182.3 mM), Sonication is recommended. Ethanol: 26 mg/mL (189.59 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2 mg/mL (14.58 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||