KLHL12 (C-Term) Rabbit pAb
Référence MBS8552891-0,1mL-Cy5.5
Conditionnement : 0.1mL(Cy5.5)
Marque : MyBiosource
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KLHL12 Antibody – Rabbit Polyclonal
For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8552891MBS8552891 is an antibody targeting KLHL12. Also known as KLHL12 (C-Term) Rabbit pAb. Reactive in Human, Mouse. Host: Rabbit. More details
Product Overview
Online Datasheet in PDFProduct Name
KLHL12, Polyclonal Antibody
Full Product Name
KLHL12 (C-Term) Rabbit pAb
Product Gene Name
anti-KLHL12 antibody
Product Synonym Names
Kelch-like protein 12; CUL3-interacting protein 1; DKIR homolog; hDKIR; KLHL12; C3IP1
Clonality
Polyclonal
Isotype
Ig
Clone Number
RB37184
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied in PBS with 0.09% (W/V) Sodium Azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Affinity Purified
OMIM
614522
Immunogen
This KLHL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 376-404 amino acids from the C-terminal region of human KLHL12.
Cellular Localization
Cytoplasmic Vesicle
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KLHL12 antibody
Western Blot (WB)
Application Notes for anti-KLHL12 antibody
WB: 1:1000
Other Notes
Small volumes of anti-KLHL12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Additional Details
NCBI/Uniprot data below describe general gene information for KLHL12. It may not necessarily be applicable to this product.
NCBI Official Full Name
Kelch-like protein 12
NCBI Official Synonym Full Names
kelch like family member 12
NCBI Official Symbol
KLHL12
NCBI Official Synonym Symbols
DKIR; C3IP1
UniProt Protein Name
Kelch-like protein 12
UniProt Synonym Protein Names
CUL3-interacting protein 1; DKIR homolog; hDKIR
Protein Family
Kelch-like protein
UniProt Gene Name
KLHL12
UniProt Synonym Gene Names
C3IP1; hDKIR
UniProt Entry Name
KLH12_HUMAN
NCBI Protein Information
kelch-like protein 12
NCBI Summary for KLHL12
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Show more UniProt Comments for KLHL12
KLHL12: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4. Component of the BCR(KLHL12) E3 ubiquitin ligase complex, at least composed of CUL3 and KLHL12 and RBX1. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A. Interacts with DRD4, KLHL12 and SEC31A. Ubiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: Golgi membrane; ER to Golgi transport vesicle; cytosol
Molecular Function: protein binding
Biological Process: COPII coating of Golgi vesicle; protein monoubiquitination; ER to Golgi vesicle-mediated transport; Wnt receptor signaling pathway
Show more Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: Golgi membrane; ER to Golgi transport vesicle; cytosol
Molecular Function: protein binding
Biological Process: COPII coating of Golgi vesicle; protein monoubiquitination; ER to Golgi vesicle-mediated transport; Wnt receptor signaling pathway
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
Product PubMed Publications
Products associated with anti-KLHL12 antibody
| Reference Product | PubMed Publications |
|---|---|
| CUL3 antibody | >4 publications with KLHL12 and CUL3 |
| KLHL7 antibody | >2 publications with KLHL12 and KLHL7 |
Pathways associated with anti-KLHL12 antibody
| Products by Pathway | Pathway Diagram |
|---|---|
| Canonical Wnt Signaling Pathway antibodies | Canonical Wnt Signaling Pathway Diagram |
| Disease Pathway antibodies | Disease Pathway Diagram |
| RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway antibodies | RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway Diagram |
| Signal Transduction Pathway antibodies | Signal Transduction Pathway Diagram |
| Signaling By WNT In Cancer Pathway antibodies | Signaling By WNT In Cancer Pathway Diagram |
| Signaling By Wnt Pathway antibodies | Signaling By Wnt Pathway Diagram |
| TCF Dependent Signaling In Response To WNT Pathway antibodies | TCF Dependent Signaling In Response To WNT Pathway Diagram |
| XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway antibodies | XAV939 Inhibits Tankyrase, Stabilizing AXIN Pathway Diagram |
| Degradation Of DVL Pathway antibodies | Degradation Of DVL Pathway Diagram |
| Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway antibodies | Misspliced LRP5 Mutants Have Enhanced Beta-catenin-dependent Signaling Pathway Diagram |
Organs/Tissues associated with anti-KLHL12 antibody
| Organ/Tissue Name | Pubmed Publications |
|---|---|
| Nerve Antibodies | >2 publications with KLHL12 and Nerve |
| Liver Antibodies | >2 publications with KLHL12 and Liver |
| Blood Antibodies | >1 publications with KLHL12 and Blood |
| Mouth Antibodies | >1 publications with KLHL12 and Mouth |
| Vascular Antibodies | >1 publications with KLHL12 and Vascular |
| Kidney Antibodies | >1 publications with KLHL12 and Kidney |